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IGF-1R and Leptin Expression Profile and the Effects of Metformin Treatment on Metabolic and Endocrine Parameters in PCOS Mice
Joint Authors
Prado Correia, Luis Eduardo
de Almeida, Bruna Cristine
de Jesus Simões, Manuel
Abi Haidar, Mauro
Berguio Vidotti, Daniela
Silva, Ivaldo
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We aim to assess the effects of metformin treatment on metabolic and endocrine parameters and genes expression related to the insulin-responsive pathway in polycystic ovary syndrome (PCOS).
This study comprises twenty-eight obese mice divided into three metformin-treated groups for seven and twenty days and eight nonobese and nontreated ones.
We found a significant decrease in glycemia after metformin treatment at days seven and twenty.
However, we did not observe differences in body weight measurement.
Histologically, after twenty days we observed follicular development with regression of androgenic effects.
Levels of IGF-1R protein expression were low after twenty days of treatment, but LEP proteins showed an overexpression in the ovarian stroma.
We assessed the IGF-1R and LEP mRNAs levels; data showed a significant overexpression of LEP after seven days of treatment, while the IGF-1R was downregulated.
Metformin therapy seems to exert a beneficial effect on histological and anovulatory features, reducing follicular number and pyknosis formation, possibly involved in the reversion of androgenic stimulus.
Expression of IGF-1 and LEPR indicates a relevant role in androgenic features reversion present in PCOS, hormonal equilibrium, body weight regulation, and glucose metabolism, therefore, under phenotype obesity and infertility regulation in this model.
American Psychological Association (APA)
Prado Correia, Luis Eduardo& de Almeida, Bruna Cristine& de Jesus Simões, Manuel& Abi Haidar, Mauro& Berguio Vidotti, Daniela& Silva, Ivaldo. 2017. IGF-1R and Leptin Expression Profile and the Effects of Metformin Treatment on Metabolic and Endocrine Parameters in PCOS Mice. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139313
Modern Language Association (MLA)
Prado Correia, Luis Eduardo…[et al.]. IGF-1R and Leptin Expression Profile and the Effects of Metformin Treatment on Metabolic and Endocrine Parameters in PCOS Mice. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1139313
American Medical Association (AMA)
Prado Correia, Luis Eduardo& de Almeida, Bruna Cristine& de Jesus Simões, Manuel& Abi Haidar, Mauro& Berguio Vidotti, Daniela& Silva, Ivaldo. IGF-1R and Leptin Expression Profile and the Effects of Metformin Treatment on Metabolic and Endocrine Parameters in PCOS Mice. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139313
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139313