Topical Tranexamic Acid Reduces Blood Loss in Minimally Invasive Total Knee Arthroplasty Receiving Rivaroxaban
Joint Authors
Wang, Jun-Wen
Chen, Bradley
Lin, Po-Chun
Yen, Shih-Hsiang
Huang, Chung-Chen
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
It is unclear whether topical (intra-articular) or intravenous TXA reduces blood loss in minimally invasive TKA patients receiving a direct oral anticoagulant for thromboprophylaxis.
This study is to investigate whether TXA given intravenously or intra-articularly is effective in reducing blood loss in minimally invasive TKA patients using rivaroxaban for thromboprophylaxis.
Methods.
Ninety-three patients who underwent primary minimally invasive TKA were divided into placebo group (30 patients) that received saline both intravenously and intra-articularly, intravenous (IV) group (31 patients) that received 1 g TXA intravenously, and topical group (32 patients) that received 3 g TXA in 100 ml saline intra-articularly.
All patients received oral rivaroxaban of 10 mg daily for 14 days postoperatively.
Results.
p<0.001 and p=0.041.
The mean total blood loss was 1131 mL (567–1845) in placebo, which was higher than that in the IV group (921 mL; range, 465–1495; p=0.014) and the topical group (795 mL; range, 336–1350; p<0.001).
The total blood loss did not differ between the IV and the topical group (p=0.179).
Conclusion.
This prospective, randomized, controlled trial demonstrated an equal efficacy of TXA in blood conservation when administered intravenously or topically in minimally invasive TKA patients receiving rivaroxaban for thromboprophylaxis.
American Psychological Association (APA)
Yen, Shih-Hsiang& Lin, Po-Chun& Chen, Bradley& Huang, Chung-Chen& Wang, Jun-Wen. 2017. Topical Tranexamic Acid Reduces Blood Loss in Minimally Invasive Total Knee Arthroplasty Receiving Rivaroxaban. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1139349
Modern Language Association (MLA)
Yen, Shih-Hsiang…[et al.]. Topical Tranexamic Acid Reduces Blood Loss in Minimally Invasive Total Knee Arthroplasty Receiving Rivaroxaban. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1139349
American Medical Association (AMA)
Yen, Shih-Hsiang& Lin, Po-Chun& Chen, Bradley& Huang, Chung-Chen& Wang, Jun-Wen. Topical Tranexamic Acid Reduces Blood Loss in Minimally Invasive Total Knee Arthroplasty Receiving Rivaroxaban. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1139349
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139349