Comprehensive Analysis of Differently Expressed and Methylated Genes in Preeclampsia
Joint Authors
Zhang, Ruoxi
Xu, Wenyi
Ru, Ping
Gu, Zhuorong
Pang, Xixia
Liu, Zhou
Liu, Ming
Huang, Yi
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Preeclampsia (PE) is one of the mainly caused maternal and infant incidences and mortalities worldwide.
However, the mechanisms underlying PE remained largely unclear.
The present study identified 1716 high expressions of gene and 2705 low expressions of gene using GSE60438 database, and identified 7087 hypermethylated and 15120 hypomethylated genes in preeclampsia using GSE100197.
Finally, 536 upregulated genes with hypomethylation and 322 downregulated genes with hypermethylation were for the first time revealed in PE.
Gene Ontology (GO) analysis revealed that these genes were associated with peptidyl-tyrosine phosphorylation, skeletal system development, leukocyte migration, transcription regulation, T cell receptor and IFN-γ-involved pathways, innate immune response, signal transduction, cell adhesion, angiogenesis, and hemopoiesis.
Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis demonstrated that aberrantly methylated differentially expressed genes were involved in regulating adherens junction, pluripotency of stem cell regulation, immune processing, T cell receptor and NF-κB pathways, HTLV-I and HSV infections, leishmaniasis, and NK-induced cytotoxicity.
Protein-protein interaction (PPI) network analysis identified several hub networks and key genes, including MAPK8, CCNF, CDC23, ABL1, NF1, UBE2E3, CD44, and PIK3R1.
We hope these findings will draw more attention to these hub genes in future PE studies.
American Psychological Association (APA)
Xu, Wenyi& Ru, Ping& Gu, Zhuorong& Zhang, Ruoxi& Pang, Xixia& Huang, Yi…[et al.]. 2020. Comprehensive Analysis of Differently Expressed and Methylated Genes in Preeclampsia. Computational and Mathematical Methods in Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1139365
Modern Language Association (MLA)
Xu, Wenyi…[et al.]. Comprehensive Analysis of Differently Expressed and Methylated Genes in Preeclampsia. Computational and Mathematical Methods in Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1139365
American Medical Association (AMA)
Xu, Wenyi& Ru, Ping& Gu, Zhuorong& Zhang, Ruoxi& Pang, Xixia& Huang, Yi…[et al.]. Comprehensive Analysis of Differently Expressed and Methylated Genes in Preeclampsia. Computational and Mathematical Methods in Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1139365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139365