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MicroRNA Regulation of Glycolytic Metabolism in Glioblastoma
Joint Authors
Alfardus, Huda
McIntyre, Alan
Smith, Stuart
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Glioblastoma (GBM) is the most aggressive and common malignant brain tumour in adults.
A well-known hallmark of GMB and many other tumours is aerobic glycolysis.
MicroRNAs (miRNAs) are a class of short nonprotein coding sequences that exert posttranscriptional controls on gene expression and represent critical regulators of aerobic glycolysis in GBM.
In GBM, miRNAs regulate the expression of glycolytic genes directly and via the regulation of metabolism-associated tumour suppressors and oncogenic signalling pathways.
This review aims to establish links between miRNAs expression levels, the expression of GBM glycolytic regulatory genes, and the malignant progression and prognosis of GBM.
In this review, the involvement of 25 miRNAs in the regulation of glycolytic metabolism of GBM is discussed.
Seven of these miRNAs have been shown to regulate glycolytic metabolism in other tumour types.
Further eight miRNAs, which are differentially expressed in GBM, have also been reported to regulate glycolytic metabolism in other cancer types.
Thus, these miRNAs could serve as potential glycolytic regulators in GBM but will require functional validation.
As such, the characterisation of these molecular and metabolic signatures in GBM can facilitate a better understanding of the molecular pathogenesis of this disease.
American Psychological Association (APA)
Alfardus, Huda& McIntyre, Alan& Smith, Stuart. 2017. MicroRNA Regulation of Glycolytic Metabolism in Glioblastoma. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1139367
Modern Language Association (MLA)
Alfardus, Huda…[et al.]. MicroRNA Regulation of Glycolytic Metabolism in Glioblastoma. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1139367
American Medical Association (AMA)
Alfardus, Huda& McIntyre, Alan& Smith, Stuart. MicroRNA Regulation of Glycolytic Metabolism in Glioblastoma. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1139367
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139367