Idiosyncratic Drug-Induced Liver Injury (IDILI): Potential Mechanisms and Predictive Assays
Joint Authors
Roth, Alexander D.
Lee, Moo-Yeal
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-04
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Idiosyncratic drug-induced liver injury (IDILI) is a significant source of drug recall and acute liver failure (ALF) in the United States.
While current drug development processes emphasize general toxicity and drug metabolizing enzyme- (DME-) mediated toxicity, it has been challenging to develop comprehensive models for assessing complete idiosyncratic potential.
In this review, we describe the enzymes and proteins that contain polymorphisms believed to contribute to IDILI, including ones that affect phase I and phase II metabolism, antioxidant enzymes, drug transporters, inflammation, and human leukocyte antigen (HLA).
We then describe the various assays that have been developed to detect individual reactions focusing on each of the mechanisms described in the background.
Finally, we examine current trends in developing comprehensive models for examining these mechanisms.
There is an urgent need to develop a panel of multiparametric assays for diagnosing individual toxicity potential.
American Psychological Association (APA)
Roth, Alexander D.& Lee, Moo-Yeal. 2017. Idiosyncratic Drug-Induced Liver Injury (IDILI): Potential Mechanisms and Predictive Assays. BioMed Research International،Vol. 2017, no. 2017, pp.1-23.
https://search.emarefa.net/detail/BIM-1139388
Modern Language Association (MLA)
Roth, Alexander D.& Lee, Moo-Yeal. Idiosyncratic Drug-Induced Liver Injury (IDILI): Potential Mechanisms and Predictive Assays. BioMed Research International No. 2017 (2017), pp.1-23.
https://search.emarefa.net/detail/BIM-1139388
American Medical Association (AMA)
Roth, Alexander D.& Lee, Moo-Yeal. Idiosyncratic Drug-Induced Liver Injury (IDILI): Potential Mechanisms and Predictive Assays. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-23.
https://search.emarefa.net/detail/BIM-1139388
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139388