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Antidiabetic Micro-Nanoaggregates from Ge-Gen-Qin-Lian-Tang Decoction Increase Absorption of Baicalin and Cellular Antioxidant Activity In Vitro
Joint Authors
Rao, Ping-Fan
Ke, Li-Jing
Lin, Dai
Du, Qian
Wang, Huiqin
Gao, Guanzhen
Zhou, Jianwu
Shaw, Chris
Chen, Tianbao
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The antidiabetic effects of Ge-Gen-Qin-Lian-Tang decoction (GQD) have been proven clinically.
In a pharmacological study conducted on STZ-induced diabetic rats, the constitutive aggregates/sediments of Ge-Gen-Qin-Lian-Tang decoction exhibited stronger hypoglycemic and antioxidant activities compared to the soluble compositions.
This study aims to demonstrate the pharmacological properties of aggregates derived from GQD by measuring permeability of the active monomer phytochemicals (e.g., baicalin) in a Caco-2 cell monolayer and determine the cellular viability, intracellular redox status (MDA and SOD), and insulin secretion of pancreatic β-cell line, INS-1, following STZ-induced oxidative stress.
The aggregates were separated into three fractions, namely, “MA (microaggregates),” “400 g supernatant,” and “MNA (micro-/nanoaggregates),” by centrifugation at 400 ×g and 15000 ×g, respectively.
Aggregates in the sediment increased baicalin absorption, showed little toxicity to β-cells, elevated intracellular SOD levels, and significantly suppressed oxidative damage effects on cellular viability and functions.
The “MA” fraction had a larger particle size and provided higher antioxidant cellular protection than “MNA” in vitro, implying that the sediments may be the active components in the herbal decoction.
The actions of these micro-/nanoaggregates may provide a new perspective for understanding the antidiabetic effects of herbal decoctions and aid in interpretation of synergistic actions between the multiple components.
American Psychological Association (APA)
Lin, Dai& Du, Qian& Wang, Huiqin& Gao, Guanzhen& Zhou, Jianwu& Ke, Li-Jing…[et al.]. 2017. Antidiabetic Micro-Nanoaggregates from Ge-Gen-Qin-Lian-Tang Decoction Increase Absorption of Baicalin and Cellular Antioxidant Activity In Vitro. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1139411
Modern Language Association (MLA)
Lin, Dai…[et al.]. Antidiabetic Micro-Nanoaggregates from Ge-Gen-Qin-Lian-Tang Decoction Increase Absorption of Baicalin and Cellular Antioxidant Activity In Vitro. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1139411
American Medical Association (AMA)
Lin, Dai& Du, Qian& Wang, Huiqin& Gao, Guanzhen& Zhou, Jianwu& Ke, Li-Jing…[et al.]. Antidiabetic Micro-Nanoaggregates from Ge-Gen-Qin-Lian-Tang Decoction Increase Absorption of Baicalin and Cellular Antioxidant Activity In Vitro. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1139411
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139411