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Network Structure Analysis Identifying Key Genes of Autism and Its Mechanism
Joint Authors
Meng, Dazhi
Wang, Yanhui
Kou, Yanming
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Identifying the key genes of autism is of great significance for understanding its pathogenesis and improving the clinical level of medicine.
In this paper, we use the structural parameters (average degree) of gene correlation networks to identify genes related to autism and study its pathogenesis.
Based on the gene expression profiles of 82 autistic patients (the experimental group, E) and 64 healthy persons (the control group, C) in NCBI database, spearman correlation networks are established, and their average degrees under different thresholds are analyzed.
It is found that average degrees of C and E are basically separable at the full thresholds.
This indicates that there is a clear difference between the network structures of C and E, and it also suggests that this difference is related to the mechanism of disease.
By annotating and enrichment analysis of the first 20 genes (MD-Gs) with significant difference in the average degree, we find that they are significantly related to gland development, cardiovascular development, and embryogenesis of nervous system, which support the results in Alter et al.’s original research.
In addition, FIGF and CSF3 may play an important role in the mechanism of autism.
American Psychological Association (APA)
Wang, Yanhui& Kou, Yanming& Meng, Dazhi. 2020. Network Structure Analysis Identifying Key Genes of Autism and Its Mechanism. Computational and Mathematical Methods in Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1139412
Modern Language Association (MLA)
Wang, Yanhui…[et al.]. Network Structure Analysis Identifying Key Genes of Autism and Its Mechanism. Computational and Mathematical Methods in Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1139412
American Medical Association (AMA)
Wang, Yanhui& Kou, Yanming& Meng, Dazhi. Network Structure Analysis Identifying Key Genes of Autism and Its Mechanism. Computational and Mathematical Methods in Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1139412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139412