Expression of Neurotrophin-3 and trkC following Focal Cerebral Ischemia in Adult Rat Brain with Treadmill Exercise

Abstract EN

Neurotrophin-3 (NT-3) is a neurotrophic factor that mainly binds to the tyrosine kinase C (trkC) receptor.

NT-3 has been shown to have neuroprotective effects in focal cerebral ischemia.

Exercise also has ability to induce functional recovery in focal cerebral ischemia.

However, the relationship between NT-3, its receptor trkC, and exercise has not been revealed.

In this study, we assessed the expressions of NT-3 and trkC in focal cerebral ischemia.

We also assessed the expression of NT-3 and trkC with treadmill exercise in focal cerebral ischemia.

The results showed that, in a permanent middle cerebral artery occlusion rat model, exercise increased NT-3 and trkC expression.

However, the patterns of expression of NT-3 and trkC at different time points varied.

These results suggest that exercise-induced functional recovery in focal cerebral ischemia was related to NT-3 and trkC, but the role on times of NT-3 and trkC differed, although trkC is the receptor kinase for NT-3.