Expression of Neurotrophin-3 and trkC following Focal Cerebral Ischemia in Adult Rat Brain with Treadmill Exercise
Joint Authors
Hwang, In Koo
Im, Wooseok
Kim, Min-Wook
Bang, Moon-Suk
Kim, Manho
Chung, Jin-Young
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Neurotrophin-3 (NT-3) is a neurotrophic factor that mainly binds to the tyrosine kinase C (trkC) receptor.
NT-3 has been shown to have neuroprotective effects in focal cerebral ischemia.
Exercise also has ability to induce functional recovery in focal cerebral ischemia.
However, the relationship between NT-3, its receptor trkC, and exercise has not been revealed.
In this study, we assessed the expressions of NT-3 and trkC in focal cerebral ischemia.
We also assessed the expression of NT-3 and trkC with treadmill exercise in focal cerebral ischemia.
The results showed that, in a permanent middle cerebral artery occlusion rat model, exercise increased NT-3 and trkC expression.
However, the patterns of expression of NT-3 and trkC at different time points varied.
These results suggest that exercise-induced functional recovery in focal cerebral ischemia was related to NT-3 and trkC, but the role on times of NT-3 and trkC differed, although trkC is the receptor kinase for NT-3.
American Psychological Association (APA)
Chung, Jin-Young& Kim, Min-Wook& Im, Wooseok& Hwang, In Koo& Bang, Moon-Suk& Kim, Manho. 2017. Expression of Neurotrophin-3 and trkC following Focal Cerebral Ischemia in Adult Rat Brain with Treadmill Exercise. BioMed Research International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1139419
Modern Language Association (MLA)
Chung, Jin-Young…[et al.]. Expression of Neurotrophin-3 and trkC following Focal Cerebral Ischemia in Adult Rat Brain with Treadmill Exercise. BioMed Research International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1139419
American Medical Association (AMA)
Chung, Jin-Young& Kim, Min-Wook& Im, Wooseok& Hwang, In Koo& Bang, Moon-Suk& Kim, Manho. Expression of Neurotrophin-3 and trkC following Focal Cerebral Ischemia in Adult Rat Brain with Treadmill Exercise. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1139419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139419