Assessment of Haemodynamic Response to Nonselective Beta-Blockers in Portal Hypertension by Phase-Contrast Magnetic Resonance Angiography
Joint Authors
Fallowfield, Jonathan
Hayes, Peter C.
Semple, S. I.
Macnaught, Gillian
McDonald, Natasha
Lilburn, David M. L.
Lachlan, Neil J.
Patel, Dilip
Jayaswal, Arjun N. A.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A significant unmet need exists for accurate, reproducible, noninvasive diagnostic tools to assess and monitor portal hypertension (PHT).
We report the first use of quantitative MRI markers for the haemodynamic assessment of nonselective beta-blockers (NSBB) in PHT.
In a randomized parallel feasibility study in 22 adult patients with PHT and a clinical indication for NSBB, we acquired haemodynamic data at baseline and after 4 weeks of NSBB (propranolol or carvedilol) using phase-contrast MR angiography (PC-MRA) in selected intra-abdominal vessels.
T1 mapping of liver and spleen was undertaken to assess changes in tissue composition.
Target NSBB dose was achieved in 82%.
There was a substantial reduction from baseline in mean average flow in the superior abdominal aorta after 4 weeks of NSBB therapy (4.49±0.98 versus 3.82±0.86 L/min, P=0.03) but there were no statistically significant differences in flow in any other vessels, even in patients with >25% decrease in heart rate (47% of patients).
Mean percentage change in liver and spleen T1 following NSBB was small and highly variable.
In conclusion, PC-MRA was able to detect reduction in cardiac output by NSBB but did not detect significant changes in visceral blood flow or T1.
This trial was registered with the ISRCTN registry (ISRCTN98001632).
American Psychological Association (APA)
McDonald, Natasha& Lilburn, David M. L.& Lachlan, Neil J.& Macnaught, Gillian& Patel, Dilip& Jayaswal, Arjun N. A.…[et al.]. 2017. Assessment of Haemodynamic Response to Nonselective Beta-Blockers in Portal Hypertension by Phase-Contrast Magnetic Resonance Angiography. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1139442
Modern Language Association (MLA)
McDonald, Natasha…[et al.]. Assessment of Haemodynamic Response to Nonselective Beta-Blockers in Portal Hypertension by Phase-Contrast Magnetic Resonance Angiography. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1139442
American Medical Association (AMA)
McDonald, Natasha& Lilburn, David M. L.& Lachlan, Neil J.& Macnaught, Gillian& Patel, Dilip& Jayaswal, Arjun N. A.…[et al.]. Assessment of Haemodynamic Response to Nonselective Beta-Blockers in Portal Hypertension by Phase-Contrast Magnetic Resonance Angiography. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1139442
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139442