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Identification of the Key Genes Involved in the Effect of Folic Acid on Endothelial Progenitor Cell Transcriptome of Patients with Type 1 Diabetes
Joint Authors
Yang, Qianhong
Hu, Wei
Dong, Jian
Lu, Yi
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Type 1 diabetes (T1D) is one of the most common autoimmune diseases in children.
Previous studies have suggested that endothelial progenitor cells (EPCs) might be engaged in the regulating of the biological processes in T1D and folic acid (FA) might be engaged in regulating EPC function.
The present study has identified 716 downregulated genes and 617 upregulated genes in T1D EPC cases after treated with FA.
Bioinformatics analysis has shown that these DEGs were engaged in regulating metabolic processes, cell proliferation-related processes, bone marrow development, cell adhesion, platelet degranulation, and cellular response to growth factor stimulus.
Furthermore, we have conducted and identified hub PPI networks.
Importantly, we have identified 6 upregulated genes (POLR2A, BDNF, CDC27, LTN1, RAB1A, and CUL2) and 8 downregulated genes (SHC1, GRIN2B, TTN, GNAL, GNB2, PTK2, TF, and TLR9) as key regulators involved in the effect of FA on endothelial progenitor cell transcriptome of patients with T1D.
We think that this study could provide novel information to understand the roles of FA in regulating EPCs of T1D patients.
American Psychological Association (APA)
Lu, Yi& Yang, Qianhong& Hu, Wei& Dong, Jian. 2020. Identification of the Key Genes Involved in the Effect of Folic Acid on Endothelial Progenitor Cell Transcriptome of Patients with Type 1 Diabetes. Computational and Mathematical Methods in Medicine،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1139443
Modern Language Association (MLA)
Lu, Yi…[et al.]. Identification of the Key Genes Involved in the Effect of Folic Acid on Endothelial Progenitor Cell Transcriptome of Patients with Type 1 Diabetes. Computational and Mathematical Methods in Medicine No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1139443
American Medical Association (AMA)
Lu, Yi& Yang, Qianhong& Hu, Wei& Dong, Jian. Identification of the Key Genes Involved in the Effect of Folic Acid on Endothelial Progenitor Cell Transcriptome of Patients with Type 1 Diabetes. Computational and Mathematical Methods in Medicine. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1139443
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139443