Serum Sclerostin Levels in Patients with Ankylosing Spondylitis and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis
Joint Authors
Shi, Jianfeng
Ying, Haijian
Shen, Bo
Du, Juping
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Current studies of serum sclerostin levels in AS and RA patients are inconsistent.
This meta-analysis was performed to identify the association of serum sclerostin level with AS and RA patients.
Methods.
Embase, PubMed, MEDLINE, and Cochrane Library databases (up to 25 January 2017) were used to collect all relevant published articles.
Studies were pooled and standard mean difference (SMD) with 95% confidence interval (CI) was calculated.
All data analyses were performed using RevMan 5.3.
Results.
Totally eight studies of AS including 420 AS patients and 317 healthy controls (HC) and three studies of RA including 145 RA patients and 127 HC were finally included in this meta-analysis.
The results revealed that the serum sclerostin levels in both AS patients (SMD=-0.14; 95% CI=[-0.39,0.11]; P=0.28) and RA patients (SMD=-0.10; 95% CI=[-0.34,0.15]; P=0.43) were not significantly different from those in HC.
Conclusion.
The difference of serum sclerostin levels in AS and RA patients was not significantly different from HC, indicating that the sclerostin may not associate with the development of AS and RA.
American Psychological Association (APA)
Shi, Jianfeng& Ying, Haijian& Du, Juping& Shen, Bo. 2017. Serum Sclerostin Levels in Patients with Ankylosing Spondylitis and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139450
Modern Language Association (MLA)
Shi, Jianfeng…[et al.]. Serum Sclerostin Levels in Patients with Ankylosing Spondylitis and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1139450
American Medical Association (AMA)
Shi, Jianfeng& Ying, Haijian& Du, Juping& Shen, Bo. Serum Sclerostin Levels in Patients with Ankylosing Spondylitis and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139450