Clinical Features and Outcome in Adult Cases of Tuberculous Meningitis in Tertiary Care Hospital in Antananarivo, Madagascar

Abstract EN

Purpose.

We aimed to describe and to assess prognosis factors in tuberculous meningitis in adult patients.

Methods.

We performed a retrospective study of case records of adult patients.

Patients classified as definite, probable, or possible tuberculous meningitis according to standardized definition criteria were included and assessed in the study.

Results.

Seventy-five patients were included in the study.

Tuberculous meningitis was classified as definite in 8 (10.7%), probable in 44 (58.7%), and possible in 23 patients (30.6%).

HIV was found in 3% of patients.

Patients were in advanced stages at admission in 82.7%.

Median duration of symptoms prior to admission was 3 weeks (IQR: 2–5).

Median time to diagnosis following admission was 5 days (IQR: 3–8).

Median CSF WCC was 75 per mm3 with lymphocytic predominance in 38 cases (52.8%).

Median CSF glucose level was 1.48 mmol/L and median CSF protein level was 1 g/L.

Mortality rate was 28%.

Age ≥ 35 years (aOR: 4.06; 95% CI: 1.16–14.26) and coma (aOR: 12.98; 95% CI: 1.13–149.16) predicted inpatient mortality.

Conclusion.

Most of the patients experienced more than 3 weeks of diagnostic delay prior to admission.

Mortality was high and occurred early after admission.

Age and coma were identified as independent prognosis factors.