Decellularized Swine Dental Pulp as a Bioscaffold for Pulp Regeneration
Joint Authors
Zhang, Chunmei
Zhu, Zhao
Hu, Lei
Gao, Zhenhua
Xu, Junji
Wang, Songlin
Fan, Zhipeng
Wang, Jinsong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Endodontic regeneration shows promise in treating dental pulp diseases; however, no suitable scaffolds exist for pulp regeneration.
Acellular natural extracellular matrix (ECM) is a favorable scaffold for tissue regeneration since the anatomical structure and ECM of the natural tissues or organs are well-preserved.
Xenogeneic ECM is superior to autologous or allogeneic ECM in tissue engineering for its unlimited resources.
This study investigated the characteristics of decellularized dental pulp ECM from swine and evaluated whether it could mediate pulp regeneration.
Dental pulps were acquired from the mandible anterior teeth of swine 12 months of age and decellularized with 10% sodium dodecyl sulfate (SDS) combined with Triton X-100.
Pulp regeneration was conducted by seeding human dental pulp stem cells into decellularized pulp and transplanted subcutaneously into nude mice for 8 weeks.
The decellularized pulp demonstrated preserved natural shape and structure without any cellular components.
Histological analysis showed excellent ECM preservation and pulp-like tissue, and newly formed mineralized tissues were regenerated after being transplanted in vivo.
In conclusion, decellularized swine dental pulp maintains ECM components favoring stem cell proliferation and differentiation, thus representing a suitable scaffold for improving clinical outcomes and functions of teeth with dental pulp diseases.
American Psychological Association (APA)
Hu, Lei& Gao, Zhenhua& Xu, Junji& Zhu, Zhao& Fan, Zhipeng& Zhang, Chunmei…[et al.]. 2017. Decellularized Swine Dental Pulp as a Bioscaffold for Pulp Regeneration. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139476
Modern Language Association (MLA)
Hu, Lei…[et al.]. Decellularized Swine Dental Pulp as a Bioscaffold for Pulp Regeneration. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1139476
American Medical Association (AMA)
Hu, Lei& Gao, Zhenhua& Xu, Junji& Zhu, Zhao& Fan, Zhipeng& Zhang, Chunmei…[et al.]. Decellularized Swine Dental Pulp as a Bioscaffold for Pulp Regeneration. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139476
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139476