Multiple Factors Involved in the Pathogenesis of White Matter Lesions
Joint Authors
Lin, Jing
Lan, Linfang
Fan, Yuhua
Wang, Dilong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
White matter lesions (WMLs), also known as leukoaraiosis (LA) or white matter hyperintensities (WMHs), are characterized mainly by hyperintensities on T2-weighted or fluid-attenuated inversion recovery (FLAIR) images.
With the aging of the population and the development of imaging technology, the morbidity and diagnostic rates of WMLs are increasing annually.
WMLs are not a benign process.
They clinically manifest as cognitive decline and the subsequent development of dementia.
Although WMLs are important, their pathogenesis is still unclear.
This review elaborates on the advances in the understanding of the pathogenesis of WMLs, focusing on anatomy, cerebral blood flow autoregulation, venous collagenosis, blood brain barrier disruption, and genetic factors.
In particular, the attribution of WMLs to chronic ischemia secondary to venous collagenosis and cerebral blood flow autoregulation disruption seems reasonable.
With the development of gene technology, the effect of genetic factors on the pathogenesis of WMLs is gaining gradual attention.
American Psychological Association (APA)
Lin, Jing& Wang, Dilong& Lan, Linfang& Fan, Yuhua. 2017. Multiple Factors Involved in the Pathogenesis of White Matter Lesions. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139498
Modern Language Association (MLA)
Lin, Jing…[et al.]. Multiple Factors Involved in the Pathogenesis of White Matter Lesions. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1139498
American Medical Association (AMA)
Lin, Jing& Wang, Dilong& Lan, Linfang& Fan, Yuhua. Multiple Factors Involved in the Pathogenesis of White Matter Lesions. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139498
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139498