Antifatigue Effects of Antrodia cinnamomea Cultured Mycelium via Modulation of Oxidative Stress Signaling in a Mouse Model
Joint Authors
Li, Lanzhou
Liu, Yange
An, Shengshu
Zhang, Yuanzhu
Feng, Shiwei
Zhao, Lu
Wang, Di
Teng, Lirong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Antrodia cinnamomea, a folk medicinal mushroom, has numerous biological effects.
In this study, we aim to assess whether the antifatigue effects of A.
cinnamomea mycelia (AC) and its underlying mechanisms are related to oxidative stress signaling using behavioral mouse models and biochemical indices detection.
Mice were orally treated with AC at doses of 0.1, 0.3, and 0.9 g/kg for three weeks.
AC had no effect on the spontaneous activities of mice indicating its safety on central nervous system.
Furthermore, results obtained from weight-loaded forced swimming test, rotary rod test, and exhausted running test confirmed that AC significantly enhanced exercise tolerance of mice.
Biochemical indices levels showed that these effects were closely correlated with inhibiting the depletion of glycogen and adenosine triphosphate stores, regulating oxidative stress-related parameters (superoxide dismutase, glutathione peroxidase, reactive oxygen species, and malondialdehyde) in serum, skeletal muscle, and liver of mice.
Moreover, the effects of AC may be related with its regulation on the activations of AMP-activated protein kinase, protein kinase B, and mammalian target of rapamycin in liver and skeletal muscle of mice.
Altogether, our data suggest that the antifatigue properties of AC may be one such modulation mechanism via oxidative stress-related signaling in mice.
American Psychological Association (APA)
Liu, Yange& Li, Lanzhou& An, Shengshu& Zhang, Yuanzhu& Feng, Shiwei& Zhao, Lu…[et al.]. 2017. Antifatigue Effects of Antrodia cinnamomea Cultured Mycelium via Modulation of Oxidative Stress Signaling in a Mouse Model. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139503
Modern Language Association (MLA)
Liu, Yange…[et al.]. Antifatigue Effects of Antrodia cinnamomea Cultured Mycelium via Modulation of Oxidative Stress Signaling in a Mouse Model. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1139503
American Medical Association (AMA)
Liu, Yange& Li, Lanzhou& An, Shengshu& Zhang, Yuanzhu& Feng, Shiwei& Zhao, Lu…[et al.]. Antifatigue Effects of Antrodia cinnamomea Cultured Mycelium via Modulation of Oxidative Stress Signaling in a Mouse Model. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139503
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139503