Clinical Implications of Oscillatory Lung Function during Methacholine Bronchoprovocation Testing of Preschool Children
Joint Authors
Han, Man Yong
Lee, Seung-Jin
Sheen, Youn Ho
Rha, Yeong-Ho
Choi, Sun Hee
Kim, Mi Ae
Baek, Ji Hyeon
Baek, Hey Sung
Yoon, Jung Won
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To investigate the repeatability and safety of measuring impulse oscillation system (IOS) parameters and the point of wheezing during bronchoprovocation testing of preschool children.
Methods.
Two sets of methacholine challenge were conducted in 36 asthma children.
The test was discontinued if there was a significant change in reactance (Xrs5) and resistance (Rrs5) at 5 Hz (Condition 1) or respiratory distress due to airway obstruction (Condition 2).
The repeatability of PC80_Xrs5, PC30_Rrs5, and wheezing (PCw) was assessed.
The changes in Z-scores and SD-indexes from prebaseline (before testing) to postbaseline (after bronchodilator) were determined.
Results.
For PC30_Rrs5, PC80_Xrs5, and PCw for subjects, PC80_Xrs5 showed the highest repeatability.
Fifteen of 70 tests met Condition 2.
The changes from pre- and postbaseline values varied significantly for Rrs5 and Xrs5.
Excluding subjects with Z-scores higher than 2SD, we were able to detect 97.1% of bronchial hyperresponsiveness during methacholine challenge based on the change in Rrs5 or Xrs5.
A change in IOS parameters was associated with wheezing at all frequencies.
Conclusion.
Xrs5 and Rrs5 have repeatability comparable with FEV1, and Xrs5 is more reliable than Rrs5.
Clinicians can safely perform a challenge test by measuring the changes in Rrs5, Xrs5, and Z-scores from the prebaseline values.
American Psychological Association (APA)
Choi, Sun Hee& Sheen, Youn Ho& Kim, Mi Ae& Baek, Ji Hyeon& Baek, Hey Sung& Lee, Seung-Jin…[et al.]. 2017. Clinical Implications of Oscillatory Lung Function during Methacholine Bronchoprovocation Testing of Preschool Children. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139540
Modern Language Association (MLA)
Choi, Sun Hee…[et al.]. Clinical Implications of Oscillatory Lung Function during Methacholine Bronchoprovocation Testing of Preschool Children. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1139540
American Medical Association (AMA)
Choi, Sun Hee& Sheen, Youn Ho& Kim, Mi Ae& Baek, Ji Hyeon& Baek, Hey Sung& Lee, Seung-Jin…[et al.]. Clinical Implications of Oscillatory Lung Function during Methacholine Bronchoprovocation Testing of Preschool Children. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139540