Patients Affected by Unmethylated O(6)‎-Methylguanine-DNA Methyltransferase Glioblastoma Undergoing Radiochemotherapy May Benefit from Moderately Dose-Escalated Radiotherapy

Joint Authors

Miracco, Clelia
Pastina, Pierpaolo
Battaglia, Giuseppe
Nardone, Valerio
Cerase, Alfonso
Sebaste, Lucio
Rubino, Giovanni
Tini, Paolo
Pirtoli, Luigi

Source

BioMed Research International

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-10-12

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Medicine

Abstract EN

Purpose.

To compare the therapeutic results of two radiotherapy (RT) dose schedules in combined temozolomide- (TMZ-) RT treatment in newly diagnosed glioblastoma (GB), according to the O(6)-methylguanine-DNA methyltransferase (MGMT) methylation status.

Material and Method.

Patients received either standard (60 Gy) or moderately escalated dose (70 Gy) radiotherapy (RT) with concomitant and adjuvant TMZ between June 2006 and October 2013.

We retrospectively evaluated the therapeutic effectiveness of RT schedules in terms of Overall Survival (OS) and Progression-Disease Free Survival (PDFS) analyzing the MGMT methylation status.

Results.

One hundred and seventeen patients were selected for the present analysis.

Seventy-two out of the selected cases received the standard RT-TMZ course (SDRT-TMZ) whereas the remaining 45 underwent the escalated schedule (HDRT-TMZ).

The analysis according to the MGMT promoter methylation status showed that, in unmethylated-MGMT GB patients, HDRT-TMZ and SDRT-TMZ groups had different median OS (p=0,01) and PDFS (p=0,007), that is, 8 months and 5 months for the SDRT-TMZ group and 14 months and 9 months for the HDRT-TMZ group, respectively.

No difference in survival outcomes was found in methylated MGMT patients according to the two RT schedules (p=0,12).

Conclusions.

In our experience, unmethylated-MGMT GB patients benefited from a moderately escalated dose of RT plus TMZ.

American Psychological Association (APA)

Tini, Paolo& Nardone, Valerio& Pastina, Pierpaolo& Battaglia, Giuseppe& Miracco, Clelia& Sebaste, Lucio…[et al.]. 2017. Patients Affected by Unmethylated O(6)-Methylguanine-DNA Methyltransferase Glioblastoma Undergoing Radiochemotherapy May Benefit from Moderately Dose-Escalated Radiotherapy. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139542

Modern Language Association (MLA)

Tini, Paolo…[et al.]. Patients Affected by Unmethylated O(6)-Methylguanine-DNA Methyltransferase Glioblastoma Undergoing Radiochemotherapy May Benefit from Moderately Dose-Escalated Radiotherapy. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1139542

American Medical Association (AMA)

Tini, Paolo& Nardone, Valerio& Pastina, Pierpaolo& Battaglia, Giuseppe& Miracco, Clelia& Sebaste, Lucio…[et al.]. Patients Affected by Unmethylated O(6)-Methylguanine-DNA Methyltransferase Glioblastoma Undergoing Radiochemotherapy May Benefit from Moderately Dose-Escalated Radiotherapy. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139542

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1139542