Integrated Genome-Wide Methylation and Expression Analyses Reveal Key Regulators in Osteosarcoma
Joint Authors
Wang, Fei
Liu, Junzhi
Wang, Xiunan
Qin, Guoqing
Ye, Baoguo
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Osteosarcoma (OS) is one of the most common types of primary bone tumors in early adolescence with unsatisfied prognosis.
Aberrant DNA methylation had been demonstrated to be related to tumorigenesis and progression of multiple cancers and could serve as the potential biomarkers for the prognosis of human cancers.
In conclusion, this study identified 18 downregulated hypomethylation genes and 52 upregulated hypomethylation genes in OS by integrating the analysis the GSE97529 and GSE42572 datasets.
Bioinformatics analysis revealed that OS-specific methylated genes were involved in regulating multiple biological processes, including chemical synaptic transmission, transcription, response to drug, and regulating immune response.
KEGG pathway analysis showed that OS-specific methylated genes were associated with the regulation of Hippo, cAMP calcium, MAPK, and Wnt signaling pathways.
By analyzing R2 datasets, this study showed that the dysregulation of these OS-specific methylated genes was associated with the metastasis-free survival time in patients with OS, including CBLN4, ANKMY1, BZW1, KRTCAP3, GZMB, KRTDAP, LY9, PFKFB2, PTPN22, and CLDN7.
This study provided a better understanding of the molecular mechanisms underlying the progression and OS and novel biomarkers for the prognosis of OS.
American Psychological Association (APA)
Wang, Fei& Qin, Guoqing& Liu, Junzhi& Wang, Xiunan& Ye, Baoguo. 2020. Integrated Genome-Wide Methylation and Expression Analyses Reveal Key Regulators in Osteosarcoma. Computational and Mathematical Methods in Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1139543
Modern Language Association (MLA)
Wang, Fei…[et al.]. Integrated Genome-Wide Methylation and Expression Analyses Reveal Key Regulators in Osteosarcoma. Computational and Mathematical Methods in Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1139543
American Medical Association (AMA)
Wang, Fei& Qin, Guoqing& Liu, Junzhi& Wang, Xiunan& Ye, Baoguo. Integrated Genome-Wide Methylation and Expression Analyses Reveal Key Regulators in Osteosarcoma. Computational and Mathematical Methods in Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1139543
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139543