Antithrombotic Effect and Mechanism of Radix Paeoniae Rubra
Joint Authors
Kang, Wenyi
Xie, Pingyao
Cui, Lili
Shan, Yuan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The compounds of Radix Paeoniae Rubra (RPR) were isolated and identified by bioassay-guided method, and antithrombotic effects and mechanism were investigated by the acute blood stasis rat model.
The RPR extract was evaluated by APTT, TT, PT, and FIB assays in vitro.
Results indicated that RPR extract exhibited the anticoagulant activity.
In order to find active compounds, six compounds were isolated and identified, and four compounds, paeoniflorin (Pae), pentagalloylglucose (Pen), albiflorin (Ali), and protocatechuic acid (Pro), exhibited the anticoagulant activity in vitro.
Therefore, the antithrombosis effects of RPR extract and four active compounds were investigated in vivo by measuring whole blood viscosity (WBV), plasma viscosity (PV), APTT, PT, TT, and FIB.
Meanwhile, the levels of TXB2, 6-Keto-PGF1α, eNOS, and ET-1 were detected.
Results suggested that RPR extract and four active compounds had the inhibition effect on thrombus formation, and the antithrombotic effects were associated with the regulation of vascular endothelium active substance, activating blood flow and anticoagulation effect.
American Psychological Association (APA)
Xie, Pingyao& Cui, Lili& Shan, Yuan& Kang, Wenyi. 2017. Antithrombotic Effect and Mechanism of Radix Paeoniae Rubra. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139552
Modern Language Association (MLA)
Xie, Pingyao…[et al.]. Antithrombotic Effect and Mechanism of Radix Paeoniae Rubra. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1139552
American Medical Association (AMA)
Xie, Pingyao& Cui, Lili& Shan, Yuan& Kang, Wenyi. Antithrombotic Effect and Mechanism of Radix Paeoniae Rubra. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139552
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139552