High Platelet-to-Lymphocyte Ratio Predicts Poor Prognosis and Clinicopathological Characteristics in Patients with Breast Cancer: A Meta-Analysis
Joint Authors
Song, Yong-xi
Huang, Xuan-zhang
Gao, Peng
Sun, Jing-xu
Wang, Zhen-ning
Zhang, Miao
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
We aimed to evaluate the correlation of platelet-to-lymphocyte ratio (PLR) with prognosis and clinicopathological characteristics of breast cancer.
Methods.
The PubMed and Embase databases were searched.
Hazard ratio (HR) with 95% confidence interval (CI) was used to summarize disease-free survival (DFS) and overall survival (OS).
Odds ratio (OR) was used to summarize tumor clinicopathological characteristics.
Results.
High PLR was associated with poor DFS and OS (DFS: HR = 1.47, 95% CI = 1.16–1.85, and Tau2 = 0.070; OS: HR = 1.88, 95% CI = 1.27–2.80, and Tau2 = 0.192).
A Galbraith plot indicated that the studies by Allan et al.
and Cihan et al.
contributed the heterogeneity of DFS and OS, respectively.
There were significant differences in the incidence of high PLR between stage II–IV and stage I groups (OR = 1.86, 95% CI = 1.20–2.90, and Tau2 < 0.001), between lymph node-positive and lymph node-negative groups (OR = 1.52, 95% CI = 1.22–1.91, and Tau2 =0.014), and between metastasis-positive and metastasis-negative groups (OR = 4.24, 95% CI = 2.73–6.59, and Tau2 < 0.001).
Conclusions.
Our results indicated that PLR was associated with poor prognosis of breast cancer and adequately predicted clinicopathological characteristics.
American Psychological Association (APA)
Zhang, Miao& Huang, Xuan-zhang& Song, Yong-xi& Gao, Peng& Sun, Jing-xu& Wang, Zhen-ning. 2017. High Platelet-to-Lymphocyte Ratio Predicts Poor Prognosis and Clinicopathological Characteristics in Patients with Breast Cancer: A Meta-Analysis. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139570
Modern Language Association (MLA)
Zhang, Miao…[et al.]. High Platelet-to-Lymphocyte Ratio Predicts Poor Prognosis and Clinicopathological Characteristics in Patients with Breast Cancer: A Meta-Analysis. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1139570
American Medical Association (AMA)
Zhang, Miao& Huang, Xuan-zhang& Song, Yong-xi& Gao, Peng& Sun, Jing-xu& Wang, Zhen-ning. High Platelet-to-Lymphocyte Ratio Predicts Poor Prognosis and Clinicopathological Characteristics in Patients with Breast Cancer: A Meta-Analysis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139570
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139570