A Simple Cardiovascular Model for the Study of Hemorrhagic Shock
Joint Authors
Curcio, Luciano
D’Orsi, Laura
Cibella, Fabio
Wagnert-Avraham, Linn
Nachman, Dean
De Gaetano, Andrea
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-28
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Hemorrhagic shock is the number one cause of death on the battlefield and in civilian trauma as well.
Mathematical modeling has been applied in this context for decades; however, the formulation of a satisfactory model that is both practical and effective has yet to be achieved.
This paper introduces an upgraded version of the 2007 Zenker model for hemorrhagic shock termed the ZenCur model that allows for a better description of the time course of relevant observations.
Our study provides a simple but realistic mathematical description of cardiovascular dynamics that may be useful in the assessment and prognosis of hemorrhagic shock.
This model is capable of replicating the changes in mean arterial pressure, heart rate, and cardiac output after the onset of bleeding (as observed in four experimental laboratory animals) and achieves a reasonable compromise between an overly detailed depiction of relevant mechanisms, on the one hand, and model simplicity, on the other.
The former would require considerable simulations and entail burdensome interpretations.
From a clinical standpoint, the goals of the new model are to predict survival and optimize the timing of therapy, in both civilian and military scenarios.
American Psychological Association (APA)
Curcio, Luciano& D’Orsi, Laura& Cibella, Fabio& Wagnert-Avraham, Linn& Nachman, Dean& De Gaetano, Andrea. 2020. A Simple Cardiovascular Model for the Study of Hemorrhagic Shock. Computational and Mathematical Methods in Medicine،Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1139587
Modern Language Association (MLA)
Curcio, Luciano…[et al.]. A Simple Cardiovascular Model for the Study of Hemorrhagic Shock. Computational and Mathematical Methods in Medicine No. 2020 (2020), pp.1-21.
https://search.emarefa.net/detail/BIM-1139587
American Medical Association (AMA)
Curcio, Luciano& D’Orsi, Laura& Cibella, Fabio& Wagnert-Avraham, Linn& Nachman, Dean& De Gaetano, Andrea. A Simple Cardiovascular Model for the Study of Hemorrhagic Shock. Computational and Mathematical Methods in Medicine. 2020. Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1139587
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139587