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Hydroethanolic Extract of Strychnos pseudoquina Accelerates Skin Wound Healing by Modulating the Oxidative Status and Microstructural Reorganization of Scar Tissue in Experimental Type I Diabetes
Joint Authors
Leite, João Paulo Viana
Novaes, Rômulo Dias
Gonçalves, Reggiani Vilela
Sarandy, Mariáurea Matias
Xavier, Antônio A.
Vital, Camilo E.
Melo, Fabiana C. S. A.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The effect of topical application of ointment based on Strychnos pseudoquina hydroethanolic extract in the cutaneous wounds healing in diabetic rats was evaluated.
Samples of S.
pseudoquina were submitted to phytochemical prospection and in vitro antioxidant assay.
Thirty Wistar rats were divided into 5 groups: Sal-wounds treated with 0.9% saline solution; VH-wounds treated with 0.6 g of lanolin cream (vehicle); SS-wounds treated with silver sulfadiazine cream (10 mg/g); ES5- and ES10-wounds treated with an ointment of S.
pseudoquina extract, 5% and 10%, respectively.
Fragments of wounds were removed for histological and biochemical analysis every 7 days during 21 days.
ES showed equivalent levels per gram of extract of total phenols and flavonoids equal to 122.04 mg for TAE and 0.60 mg for RE.
The chlorogenic acid was one of the major constituents.
S.
pseudoquina extract presented high antioxidant potential in vitro.
ES5 and ES10 showed higher wound healing rate and higher amount of cells, blood vessels, and type III and I collagen.
The oxidative stress markers were lower in the ES5 and ES10 groups, while the antioxidants enzymes levels were higher.
Ointment based on S.
pseudoquina extract promotes a fast and efficient cutaneous repair in diabetic rats.
American Psychological Association (APA)
Sarandy, Mariáurea Matias& Novaes, Rômulo Dias& Xavier, Antônio A.& Vital, Camilo E.& Leite, João Paulo Viana& Melo, Fabiana C. S. A.…[et al.]. 2017. Hydroethanolic Extract of Strychnos pseudoquina Accelerates Skin Wound Healing by Modulating the Oxidative Status and Microstructural Reorganization of Scar Tissue in Experimental Type I Diabetes. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139592
Modern Language Association (MLA)
Sarandy, Mariáurea Matias…[et al.]. Hydroethanolic Extract of Strychnos pseudoquina Accelerates Skin Wound Healing by Modulating the Oxidative Status and Microstructural Reorganization of Scar Tissue in Experimental Type I Diabetes. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1139592
American Medical Association (AMA)
Sarandy, Mariáurea Matias& Novaes, Rômulo Dias& Xavier, Antônio A.& Vital, Camilo E.& Leite, João Paulo Viana& Melo, Fabiana C. S. A.…[et al.]. Hydroethanolic Extract of Strychnos pseudoquina Accelerates Skin Wound Healing by Modulating the Oxidative Status and Microstructural Reorganization of Scar Tissue in Experimental Type I Diabetes. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139592
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139592