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Reduced Transferrin Levels in Active Inflammatory Bowel Disease
Joint Authors
Matusiewicz, Malgorzata
Krzystek-Korpacka, Malgorzata
Gamian, Andrzej
Lewandowska, Paulina
Neubauer, Katarzyna
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Inflammatory bowel disease (IBD) is an inflammatory disease of unclear etiopathogenesis and challenging diagnosis, frequently complicated by anemia and malnutrition.
C-reactive protein (CRP) remains the only biochemical marker of clinical relevance.
The aim of this study was to test hypothesis that transferrin, coinfluenced by inflammation, malnutrition, anemia, and oxidative stress, may better reflect global IBD patient’s condition than any other more specific index.
Transferrin and other indices of inflammation, anemia, malnutrition, and oxidative stress were measured in 137 IBD patients (Crohn’s disease (CD): n=63 and ulcerative colitis (UC): n=74) and 97 controls.
Transferrin is reduced in active CD and UC and negatively correlates with the disease activity scores (CD: ρ=-0.49; UC: ρ=-0.52).
In UC, transferrin correlates negatively with CRP, erythrocyte sedimentation rate (ESR), leukocytes, platelets, interleukin-6, interleukin-10, and TNF-α and positively with albumins, cholesterol, hemoglobin, hematocrit, erythrocytes, iron, and paraoxonase-1.
In CD, transferrin correlates negatively with CRP, leukocytes, platelets, interleukin-1, and interleukin-6 and positively with albumins, iron, catalase, glutathione peroxidase-1, superoxide dismutase-1, and paraoxonase-1.
The associations with inflammation and anemia/malnutrition were more pronounced in UC and with oxidative stress in CD.
As UC activity marker, transferrin outperforms ESR and hemoglobin, indices used in calculating the disease clinical severity score.
American Psychological Association (APA)
Matusiewicz, Malgorzata& Neubauer, Katarzyna& Lewandowska, Paulina& Gamian, Andrzej& Krzystek-Korpacka, Malgorzata. 2017. Reduced Transferrin Levels in Active Inflammatory Bowel Disease. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1139596
Modern Language Association (MLA)
Matusiewicz, Malgorzata…[et al.]. Reduced Transferrin Levels in Active Inflammatory Bowel Disease. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1139596
American Medical Association (AMA)
Matusiewicz, Malgorzata& Neubauer, Katarzyna& Lewandowska, Paulina& Gamian, Andrzej& Krzystek-Korpacka, Malgorzata. Reduced Transferrin Levels in Active Inflammatory Bowel Disease. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1139596
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139596