Association between NLPR1, NLPR3, and P2X7R Gene Polymorphisms with Partial Seizures
Joint Authors
Jiang, Pei
He, Xin
Dang, Rui-Li
Wang, Haidong
Xu, Pengfei
Liao, Dehua
Guo, Yujin
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
Clinical and experimental evidence has clarified that the inflammatory processes within the brain play a pivotal role in the pathophysiology of seizures and epilepsy.
Inflammasomes and P2X7 purinergic receptor (P2X7R) are important mediators during the inflammatory process.
Therefore, we investigated the possible association between partial seizures and inflammasomes NLPR1, NLRP3, and P2X7R gene polymorphisms in the present study.
Method.
A total of 163 patients and 201 health controls were enrolled in this study and polymorphisms of NLPR1, NLRP3, and P2X7R genes were detected using polymerase chain reaction- (PCR-) ligase detection reaction method.
Result.
The frequency of rs878329 (G>C) genotype with C (CG + CC) was significantly lower among patients with partial seizures relative to controls (OR = 2.033, 95% CI = 1.290–3.204, p=0.002 for GC + CC versus GG).
Intriguingly, we found that the significant difference of rs878329 (G>C) genotype and allele frequency only existed among males (OR = 2.542, 95% CI = 1.344–4.810, p=0.004 for GC + CC versus GG), while there was no statistically significant difference among females.
However, no significant results were presented for the genotype distributions of rs8079034, rs4612666, rs10754558, rs2027432, rs3751143, and rs208294 polymorphisms between patients and controls.
Conclusion.
Our study demonstrated the potentially significant role of NLRP1 rs878329 (G>C) in developing susceptibility to the partial seizures in a Chinese Han population.
American Psychological Association (APA)
Wang, Haidong& Xu, Pengfei& Liao, Dehua& Dang, Rui-Li& He, Xin& Guo, Yujin…[et al.]. 2017. Association between NLPR1, NLPR3, and P2X7R Gene Polymorphisms with Partial Seizures. BioMed Research International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1139604
Modern Language Association (MLA)
Wang, Haidong…[et al.]. Association between NLPR1, NLPR3, and P2X7R Gene Polymorphisms with Partial Seizures. BioMed Research International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1139604
American Medical Association (AMA)
Wang, Haidong& Xu, Pengfei& Liao, Dehua& Dang, Rui-Li& He, Xin& Guo, Yujin…[et al.]. Association between NLPR1, NLPR3, and P2X7R Gene Polymorphisms with Partial Seizures. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1139604
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139604