![](/images/graphics-bg.png)
Inhibition of Pseudomonas aeruginosa Biofilm Formation by Traditional Chinese Medicinal Herb Herba patriniae
Joint Authors
Fu, Bo
Wu, Qiaolian
Dang, Minyan
Bai, Dangdang
Guo, Qiao
Shen, Lixin
Duan, Kangmin
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
New antimicrobial agents are urgently needed to treat infections caused by drug-resistant pathogens and by pathogens capable of persisting in biofilms.
The aim of this study was to identify traditional Chinese herbs that could inhibit biofilm formation of Pseudomonas aeruginosa, an important human pathogen that causes serious and difficult-to-treat infections in humans.
A luxCDABE-based reporter system was constructed to monitor the expression of six key biofilm-associated genes in P.
aeruginosa.
The reporters were used to screen a library of 36 herb extracts for inhibitory properties against these genes.
The results obtained indicated that the extract of Herba patriniae displayed significant inhibitory effect on almost all of these biofilm-associated genes.
Quantitative analysis showed that H.
patriniae extract was able to significantly reduce the biofilm formation and dramatically altered the structure of the mature biofilms of P.
aeruginosa.
Further studies showed H.
patriniae extract decreased exopolysaccharide production by P.
aeruginosa and promoted its swarming motility, two features disparately associated with biofilm formation.
These results provided a potential mechanism for the use of H.
patriniae to treat bacterial infections by traditional Chinese medicines and revealed a promising candidate for exploration of new drugs against P.
aeruginosa biofilm-associated infections.
American Psychological Association (APA)
Fu, Bo& Wu, Qiaolian& Dang, Minyan& Bai, Dangdang& Guo, Qiao& Shen, Lixin…[et al.]. 2017. Inhibition of Pseudomonas aeruginosa Biofilm Formation by Traditional Chinese Medicinal Herb Herba patriniae. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139619
Modern Language Association (MLA)
Fu, Bo…[et al.]. Inhibition of Pseudomonas aeruginosa Biofilm Formation by Traditional Chinese Medicinal Herb Herba patriniae. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1139619
American Medical Association (AMA)
Fu, Bo& Wu, Qiaolian& Dang, Minyan& Bai, Dangdang& Guo, Qiao& Shen, Lixin…[et al.]. Inhibition of Pseudomonas aeruginosa Biofilm Formation by Traditional Chinese Medicinal Herb Herba patriniae. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139619