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Insulin Resistance in Early Rheumatoid Arthritis Is Associated with Low Appendicular Lean Mass
Joint Authors
Lember, Margus
Müller, Raili
Kull, Mart
Valner, Annika
Põlluste, Kaja
Kallikorm, Riina
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In established rheumatoid arthritis (RA), the presence of insulin resistance (IR) is well proven but, in the early stage of the disease, data are inconclusive.
We evaluated the presence of IR and associations with body composition (BC) parameters among early RA (ERA) and control subjects.
The study group consisted of 92 ERA and 321 control subjects.
Using homeostatic model assessment of IR (HOMA-IR), the cut-off value for IR was 2.15.
56% of the ERA patients and 25% of the controls had IR.
Of the BC parameters, patients with early RA had less fat-free mass and appendicular lean mass (ALM).
In multivariable model, ERA group (b-Coefficient) (4.8, CI: 2.6–8.8), male gender (7.7, CI: 2.7–22.1), and fat mass index (1.2, CI: 1.1–1.4) were associated with IR.
Insulin-resistant ERA patients had higher inflammatory markers and higher disease activity.
In the multivariable model in the ERA group, IR was associated with male gender (b-Coefficient) (7.4, CI: 153–34.9), high disease activity (6.2, CI: 1.7–22.2), and lower ALM (0.03, CI: 0.001–0.97).
IR develops in the early stage of RA in the majority of patients.
IR is more common among males and is associated with RA disease activity and lower ALM.
American Psychological Association (APA)
Müller, Raili& Kull, Mart& Lember, Margus& Põlluste, Kaja& Valner, Annika& Kallikorm, Riina. 2017. Insulin Resistance in Early Rheumatoid Arthritis Is Associated with Low Appendicular Lean Mass. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1139621
Modern Language Association (MLA)
Müller, Raili…[et al.]. Insulin Resistance in Early Rheumatoid Arthritis Is Associated with Low Appendicular Lean Mass. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1139621
American Medical Association (AMA)
Müller, Raili& Kull, Mart& Lember, Margus& Põlluste, Kaja& Valner, Annika& Kallikorm, Riina. Insulin Resistance in Early Rheumatoid Arthritis Is Associated with Low Appendicular Lean Mass. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1139621
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139621