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Clinical and Prognostic Effect of Plasma Fibrinogen in Renal Cell Carcinoma: A Meta-Analysis
Joint Authors
Kaushik, Dharam
Tian, Yuejun
Hong, Mei
Jing, Suoshi
Liu, Xingchen
Wang, Hanzhang
Wang, Xinping
Rodriguez, Ronald
Wang, Zhiping
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Although numerous studies have shown that plasma fibrinogen is linked to renal cell carcinoma (RCC) risk, the consistency and magnitude of the effect of plasma fibrinogen are unclear.
The aim of the study was to explore the association between plasma fibrinogen and RCC prognosis.
Methods.
An electronic search of Embase, PubMed/MEDLINE, and the Cochrane databases was performed to identify relevant studies published prior to June 1, 2016.
Results.
A total of 3744 patients with RCC from 7 published studies were included in the meta-analysis.
The prognostic and clinical relevance of plasma fibrinogen are evaluated in RCC patients.
Statistical significance of the combined hazard ratio (HR) was detected for overall survival, cancer-specific survival, and disease-free survival.
Our pooled results showed that elevated plasma fibrinogen was significantly associated with clinical stage and Fuhrman grading.
The level of plasma fibrinogen was not found to be associated with tumor type and gender.
Conclusions.
Elevated plasma fibrinogen is a strong indicator of poorer prognosis of patients with RCC, whereas the plasma fibrinogen is not significantly associated with tumor type.
Therefore, plasma fibrinogen could be used in patients with RCC for risk stratification and decision providing a proper therapeutic strategy.
American Psychological Association (APA)
Tian, Yuejun& Hong, Mei& Jing, Suoshi& Liu, Xingchen& Wang, Hanzhang& Wang, Xinping…[et al.]. 2017. Clinical and Prognostic Effect of Plasma Fibrinogen in Renal Cell Carcinoma: A Meta-Analysis. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1139626
Modern Language Association (MLA)
Tian, Yuejun…[et al.]. Clinical and Prognostic Effect of Plasma Fibrinogen in Renal Cell Carcinoma: A Meta-Analysis. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1139626
American Medical Association (AMA)
Tian, Yuejun& Hong, Mei& Jing, Suoshi& Liu, Xingchen& Wang, Hanzhang& Wang, Xinping…[et al.]. Clinical and Prognostic Effect of Plasma Fibrinogen in Renal Cell Carcinoma: A Meta-Analysis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1139626
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139626