PredAmyl-MLP: Prediction of Amyloid Proteins Using Multilayer Perceptron
Joint Authors
Liu, Xiaoyan
Li, Yanjuan
Zhang, Zitong
Teng, Zhixia
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Amyloid is generally an aggregate of insoluble fibrin; its abnormal deposition is the pathogenic mechanism of various diseases, such as Alzheimer’s disease and type II diabetes.
Therefore, accurately identifying amyloid is necessary to understand its role in pathology.
We proposed a machine learning-based prediction model called PredAmyl-MLP, which consists of the following three steps: feature extraction, feature selection, and classification.
In the step of feature extraction, seven feature extraction algorithms and different combinations of them are investigated, and the combination of SVMProt-188D and tripeptide composition (TPC) is selected according to the experimental results.
In the step of feature selection, maximum relevant maximum distance (MRMD) and binomial distribution (BD) are, respectively, used to remove the redundant or noise features, and the appropriate features are selected according to the experimental results.
In the step of classification, we employed multilayer perceptron (MLP) to train the prediction model.
The 10-fold cross-validation results show that the overall accuracy of PredAmyl-MLP reached 91.59%, and the performance was better than the existing methods.
American Psychological Association (APA)
Li, Yanjuan& Zhang, Zitong& Teng, Zhixia& Liu, Xiaoyan. 2020. PredAmyl-MLP: Prediction of Amyloid Proteins Using Multilayer Perceptron. Computational and Mathematical Methods in Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1139634
Modern Language Association (MLA)
Li, Yanjuan…[et al.]. PredAmyl-MLP: Prediction of Amyloid Proteins Using Multilayer Perceptron. Computational and Mathematical Methods in Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1139634
American Medical Association (AMA)
Li, Yanjuan& Zhang, Zitong& Teng, Zhixia& Liu, Xiaoyan. PredAmyl-MLP: Prediction of Amyloid Proteins Using Multilayer Perceptron. Computational and Mathematical Methods in Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1139634
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139634