Vascular Tissue Engineering: Effects of Integrating Collagen into a PCL Based Nanofiber Material
Joint Authors
Horch, Raymund E.
Arkudas, Andreas
Beier, Justus P.
Bertram, Ulf
Steiner, Dominik
Poppitz, Benjamin
Dippold, Dirk
Köhn, Katrin
Detsch, Rainer
Schubert, Dirk W.
Boccaccini, Aldo R.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The engineering of vascular grafts is a growing field in regenerative medicine.
Although numerous attempts have been made, the current vascular grafts made of polyurethane (PU), Dacron®, or Teflon® still display unsatisfying results.
Electrospinning of biopolymers and native proteins has been in the focus of research to imitate the extracellular matrix (ECM) of vessels to produce a small caliber, off-the-shelf tissue engineered vascular graft (TEVG) as a substitute for poorly performing PU, Dacron, or Teflon prostheses.
Blended poly-ε-caprolactone (PCL)/collagen grafts have shown promising results regarding biomechanical and cell supporting features.
In order to find a suitable PCL/collagen blend, we fabricated plane electrospun PCL scaffolds using various collagen type I concentrations ranging from 5% to 75%.
We analyzed biocompatibility and morphological aspects in vitro.
Our results show beneficial features of collagen I integration regarding cell viability and functionality, but also adverse effects like the loss of a confluent monolayer at high concentrations of collagen.
Furthermore, electrospun PCL scaffolds containing 25% collagen I seem to be ideal for engineering vascular grafts.
American Psychological Association (APA)
Bertram, Ulf& Steiner, Dominik& Poppitz, Benjamin& Dippold, Dirk& Köhn, Katrin& Beier, Justus P.…[et al.]. 2017. Vascular Tissue Engineering: Effects of Integrating Collagen into a PCL Based Nanofiber Material. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139649
Modern Language Association (MLA)
Bertram, Ulf…[et al.]. Vascular Tissue Engineering: Effects of Integrating Collagen into a PCL Based Nanofiber Material. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1139649
American Medical Association (AMA)
Bertram, Ulf& Steiner, Dominik& Poppitz, Benjamin& Dippold, Dirk& Köhn, Katrin& Beier, Justus P.…[et al.]. Vascular Tissue Engineering: Effects of Integrating Collagen into a PCL Based Nanofiber Material. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139649
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139649