Genetic Mutations and Epigenetic Modifications: Driving Cancer and Informing Precision Medicine
Joint Authors
Coyle, Krysta Mila
Boudreau, Jeanette E.
Marcato, Paola
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-08
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Cancer treatment is undergoing a significant revolution from “one-size-fits-all” cytotoxic therapies to tailored approaches that precisely target molecular alterations.
Precision strategies for drug development and patient stratification, based on the molecular features of tumors, are the next logical step in a long history of approaches to cancer therapy.
In this review, we discuss the history of cancer treatment from generic natural extracts and radical surgical procedures to site-specific and combinatorial treatment regimens, which have incrementally improved patient outcomes.
We discuss the related contributions of genetics and epigenetics to cancer progression and the response to targeted therapies and identify challenges and opportunities for the success of precision medicine.
The identification of patients who will benefit from targeted therapies is more complex than simply identifying patients whose tumors harbour the targeted aberration, and intratumoral heterogeneity makes it difficult to determine if a precision therapy is successful during treatment.
This heterogeneity enables tumors to develop resistance to targeted approaches; therefore, the rational combination of therapeutic agents will limit the threat of acquired resistance to therapeutic success.
By incorporating the view of malignant transformation modulated by networks of genetic and epigenetic interactions, molecular strategies will enable precision medicine for effective treatment across cancer subtypes.
American Psychological Association (APA)
Coyle, Krysta Mila& Boudreau, Jeanette E.& Marcato, Paola. 2017. Genetic Mutations and Epigenetic Modifications: Driving Cancer and Informing Precision Medicine. BioMed Research International،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1139655
Modern Language Association (MLA)
Coyle, Krysta Mila…[et al.]. Genetic Mutations and Epigenetic Modifications: Driving Cancer and Informing Precision Medicine. BioMed Research International No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1139655
American Medical Association (AMA)
Coyle, Krysta Mila& Boudreau, Jeanette E.& Marcato, Paola. Genetic Mutations and Epigenetic Modifications: Driving Cancer and Informing Precision Medicine. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1139655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139655