Contribution of the Microenvironmental Niche to Glioblastoma Heterogeneity
Joint Authors
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Glioblastoma is the most aggressive cancer of the brain.
The dismal prognosis is largely attributed to the heterogeneous nature of the tumor, which in addition to intrinsic molecular and genetic changes is also influenced by the microenvironmental niche in which the glioma cells reside.
The cancer stem cells (CSCs) hypothesis suggests that all cancers arise from CSCs that possess the ability to self-renew and initiate tumor formation.
CSCs reside in specialized niches where interaction with the microenvironment regulates their stem cell behavior.
The reciprocal interaction between glioma stem cells (GSCs) and cells from the microenvironment, such as endothelial cells, immune cells, and other parenchymal cells, may also promote angiogenesis, invasion, proliferation, and stemness of the GSCs and be likely to have an underappreciated role in their responsiveness to therapy.
This crosstalk may also promote molecular transition of GSCs.
Hence the inherent plasticity of GSCs can be seen as an adaptive response, changing according to the signaling cue from the niche.
Given the association of GSCs with tumor recurrence and treatment sensitivity, understanding this bidirectional crosstalk between GSCs and its niche may provide a framework to identify more effective therapeutic targets and improve treatment outcome.
American Psychological Association (APA)
Ho, Ivy A. W.& Shim, Winston. 2017. Contribution of the Microenvironmental Niche to Glioblastoma Heterogeneity. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1139665
Modern Language Association (MLA)
Ho, Ivy A. W.& Shim, Winston. Contribution of the Microenvironmental Niche to Glioblastoma Heterogeneity. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1139665
American Medical Association (AMA)
Ho, Ivy A. W.& Shim, Winston. Contribution of the Microenvironmental Niche to Glioblastoma Heterogeneity. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1139665
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139665