The Diagnostic Value of Nuclear Matrix Proteins in Bladder Cancer in the Aspect of Environmental Risk from Carcinogens
Joint Authors
Zdrojowy, Romuald
Szymańska, B.
Długosz, A.
Sawicka, Ewa
Guzik, Anna
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
The interaction of environmental factors with genetic susceptibility and detoxification level seems to be an important causative factor in bladder cancer (BC).
The aim of this study was to look for a BC marker panel which reflects the environmental risk.
The nuclear matrix protein 22 (NMP22), bladder cancer-4 (BLCA-4), and total level proteins NMP22 and BLCA-4 (NMBL) in BC patients with genetic predisposition NAT2 (classified as slow acetylators, SA), DNA damage (8-OHdG), and detoxification by isoenzyme GSTπ activity were measured.
Materials and Methods.
The urine and blood from 91 BC patients and controls were examined, also according to tumor stage (T) and grade (G).
The participants completed a questionnaire in order to evaluate environmental risk.
Results.
Most patients (75.3%) were previous or actual smokers.
The levels of 8-OHdG, NMP22, BLCA-4, NMBL, and GSTπ were significantly higher in BC (p≤0.001).
The majority of patients (59.3%) were slow acetylators (SA).
The highest BLCA-4/8-OHdG correlation was observed in total BC and SA smokers.
Conclusions.
The total pool of nuclear matrix proteins in the urine (NMBL) has a higher diagnostic value in bladder cancer than single proteins.
The particular value of BLCA-4 and GSTπ in the aspect of environmental risk was noted.
American Psychological Association (APA)
Szymańska, B.& Sawicka, Ewa& Guzik, Anna& Zdrojowy, Romuald& Długosz, A.. 2017. The Diagnostic Value of Nuclear Matrix Proteins in Bladder Cancer in the Aspect of Environmental Risk from Carcinogens. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139674
Modern Language Association (MLA)
Szymańska, B.…[et al.]. The Diagnostic Value of Nuclear Matrix Proteins in Bladder Cancer in the Aspect of Environmental Risk from Carcinogens. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1139674
American Medical Association (AMA)
Szymańska, B.& Sawicka, Ewa& Guzik, Anna& Zdrojowy, Romuald& Długosz, A.. The Diagnostic Value of Nuclear Matrix Proteins in Bladder Cancer in the Aspect of Environmental Risk from Carcinogens. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139674
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139674