Early Detection of Tibial Cartilage Degradation and Cancellous Bone Loss in an Ovariectomized Rat Model

Joint Authors

Feng, Qianjin
Chen, Wufan
Wang, Qing
Wang, Yinong
Liu, Zhiwei

Source

BioMed Research International

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-01-15

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Medicine

Abstract EN

This study aimed to investigate degradation of the articular cartilage and loss of the cancellous bone in an ovariectomized (OVX) rat model simulating early human menopausal stage.

Fourteen health female Sprague-Dawley rats were randomly divided into two groups (n=7 per group): an OVX group that underwent bilateral ovariectomy to create an OVX model with low estrogen levels and a sham group in which only the periovarian fatty tissue was exteriorized.

All the animals were sacrificed at 3 weeks after ovariectomy.

The left tibiae were harvested.

The articular cartilage at medial tibial plateau (MTP) and lateral tibial plateau (LTP) was assessed with quantitative high-frequency ultrasound.

The cancellous bone was evaluated with micro-CT.

The results indicated that, in comparison with the sham rats, the OVX rats exhibited significant alterations in acoustic parameters of the articular cartilage but insignificant changes in microarchitectural parameters of the cancellous bone in early stage of low estrogen levels.

The results of this study suggest that cartilage degradation induced by estrogen reduction was detected earlier with quantitative ultrasound than that of the cancellous bone loss in 3 wk OVX rats.

American Psychological Association (APA)

Wang, Yinong& Liu, Zhiwei& Wang, Qing& Feng, Qianjin& Chen, Wufan. 2017. Early Detection of Tibial Cartilage Degradation and Cancellous Bone Loss in an Ovariectomized Rat Model. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139682

Modern Language Association (MLA)

Wang, Yinong…[et al.]. Early Detection of Tibial Cartilage Degradation and Cancellous Bone Loss in an Ovariectomized Rat Model. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1139682

American Medical Association (AMA)

Wang, Yinong& Liu, Zhiwei& Wang, Qing& Feng, Qianjin& Chen, Wufan. Early Detection of Tibial Cartilage Degradation and Cancellous Bone Loss in an Ovariectomized Rat Model. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139682

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1139682