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Hepatotoxicity of Antimycotics Used for Invasive Fungal Infections: In Vitro Results
Joint Authors
Sauer, Martin
Doss, Sandra
Doß, Fanny
Mitzner, Steffen R.
Potschka, Heike
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
Drug-induced liver injury (DILI) is the most common cause of liver injury and a serious clinical problem; antimycotics are involved in approximately 3% of all DILI cases.
The hepatotoxicity of many drugs, including the antimycotics, is poorly screened in human models.
Methods.
In a standardized assay the cytotoxicity on hepatocytes of different concentrations (Cmax, 5x Cmax, and 10x Cmax) of the antimycotics used for systemic infections was tested.
Anidulafungin (ANI), liposomal amphotericerin B (L-AmB), caspofungin (CASPO), fluconazole (FLUCO), and voriconazole (VORI) were incubated with HepG2/C3A cells.
After incubation, the viability of cells (XTT test, LDH release, trypan blue staining), the synthesis of albumin, the cytochrome 1A2 activity, and the cell death (DNA fragmentation) were determined.
Kruskal-Wallis and Mann–Whitney tests were used for statistical analyses.
Results.
L-AmB, ANI, and CASPO showed a mild hepatotoxicity in the Cmax concentrations.
Higher concentrations of anidulafungin led to a severe impairment of hepatocyte viability and function.
The azoles FLUCO and VORI had a higher hepatotoxic potential in all concentrations.
Conclusion.
Antimycotics, especially azoles, used for systemic infections should be given with caution in patient with liver insufficiency or liver failure or high risk for this; therefore, therapeutic drug monitoring should be used.
Further studies with this approach are encouraged.
American Psychological Association (APA)
Doss, Sandra& Potschka, Heike& Doß, Fanny& Mitzner, Steffen R.& Sauer, Martin. 2017. Hepatotoxicity of Antimycotics Used for Invasive Fungal Infections: In Vitro Results. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139687
Modern Language Association (MLA)
Doss, Sandra…[et al.]. Hepatotoxicity of Antimycotics Used for Invasive Fungal Infections: In Vitro Results. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1139687
American Medical Association (AMA)
Doss, Sandra& Potschka, Heike& Doß, Fanny& Mitzner, Steffen R.& Sauer, Martin. Hepatotoxicity of Antimycotics Used for Invasive Fungal Infections: In Vitro Results. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139687