Relationship between HLA-DQ Gene Polymorphism and Hepatitis B Virus Infection
Joint Authors
Xu, Tao
Sun, Meiqun
Wang, Hongtao
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hepatitis B virus (HBV) infection is the predominant risk factor for chronic hepatitis B (CHB).
The association between HBV infection and human leukocyte antigen- (HLA-) DQ polymorphism (rs2856718 and rs7453920) has been demonstrated in other studies; however, the results were controversial or inconclusive.
Therefore, to derive a more precise estimation of the association, a meta-analysis was performed.
Crude odds ratios (ORs) and their 95% confidence intervals (CIs) were used to assess the strength of association between HLA-DQ polymorphism (rs2856718 and rs7453920) and HBV infection risk.
A total of 11 articles were used to evaluate the effect of the two polymorphisms on risk of HBV infection.
The pooled data showed that HLA-DQ rs2856718-G polymorphism showed protection against HBV infection, and rs2856718-A was a risk factor for chronic HBV infection.
The pooled risk estimates indicated that HLA-DQ rs7453920-A polymorphism was associated with decreased risk of HBV infection, and rs7453920-G serves as a risk factor in HBV infection.
However, these stratified analyses were lacking credibility due to the limitation of correlational study numbers; further investigation on a large population and different ethnicities is warranted.
American Psychological Association (APA)
Xu, Tao& Sun, Meiqun& Wang, Hongtao. 2017. Relationship between HLA-DQ Gene Polymorphism and Hepatitis B Virus Infection. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139694
Modern Language Association (MLA)
Xu, Tao…[et al.]. Relationship between HLA-DQ Gene Polymorphism and Hepatitis B Virus Infection. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1139694
American Medical Association (AMA)
Xu, Tao& Sun, Meiqun& Wang, Hongtao. Relationship between HLA-DQ Gene Polymorphism and Hepatitis B Virus Infection. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139694
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139694