Involvement of the PI3KAktNF-κB Signaling Pathway in the Attenuation of Severe Acute Pancreatitis-Associated Acute Lung Injury by Sedum sarmentosum Bunge Extract
Joint Authors
Zhou, Mengtao
Chen, Bi-Cheng
Jin, Yuepeng
Liu, Lewei
Bai, Yongyu
Zhang, Fan
Li, Qiang
Lv, Chongqing
Li, Junjian
Rubby, Sadman
Yang, Lihong
Andersson, Roland
Sun, Hongwei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-05
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Sedum sarmentosum Bunge possesses excellent anti-inflammatory properties and was used in the treatment of inflammatory diseases.
The aim of the present study was to investigate the efficiency of Sedum sarmentosum Bunge extract (SSBE) on severe acute pancreatitis-associated (SAP-associated) acute lung injury (ALI) in rats and to explore the underlying mechanisms.
Here, we used a sodium taurocholate-induced SAP rat model to determine the role of SSBE in ALI.
During the course of pancreatitis, the expressions of phosphorylated phosphoinositide 3-kinases (PI3K)/protein kinase B (Akt) and nuclear factor-kappa B (NF-κB) p65 in the lungs were upregulated.
Meanwhile, a parallel increase in the levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in the lungs was observed after the induction of SAP.
Treatment with SSBE significantly reduced the expression of p-Akt and p-p65 in the lungs and attenuated the severity of SAP-associated ALI compared to the SAP group at 12 h and 24 h.
In summary, this study showed that SSBE has beneficial effects on SAP-associated ALI, probably through the PI3-K/Akt signaling pathways by suppressing the NF-κB activities.
American Psychological Association (APA)
Jin, Yuepeng& Liu, Lewei& Chen, Bi-Cheng& Bai, Yongyu& Zhang, Fan& Li, Qiang…[et al.]. 2017. Involvement of the PI3KAktNF-κB Signaling Pathway in the Attenuation of Severe Acute Pancreatitis-Associated Acute Lung Injury by Sedum sarmentosum Bunge Extract. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1139700
Modern Language Association (MLA)
Jin, Yuepeng…[et al.]. Involvement of the PI3KAktNF-κB Signaling Pathway in the Attenuation of Severe Acute Pancreatitis-Associated Acute Lung Injury by Sedum sarmentosum Bunge Extract. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1139700
American Medical Association (AMA)
Jin, Yuepeng& Liu, Lewei& Chen, Bi-Cheng& Bai, Yongyu& Zhang, Fan& Li, Qiang…[et al.]. Involvement of the PI3KAktNF-κB Signaling Pathway in the Attenuation of Severe Acute Pancreatitis-Associated Acute Lung Injury by Sedum sarmentosum Bunge Extract. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1139700
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139700