Diagnostic Value of CK-18, FGF-21, and Related Biomarker Panel in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
Joint Authors
Yuan, Fahu
He, Lei
Deng, Linfeng
Zhang, Quan
Guo, Jianli
Zhou, Jinan
Song, Wenjian
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Liver biopsy still remains the gold standard for diagnosing nonalcoholic steatohepatitis (NASH), but with limitations.
There is an urgent need to develop noninvasive tests that accurately distinguish NASH from simple steatosis.
The purpose of this meta-analysis was to evaluate the diagnostic value of serum biomarkers including cytokeratin 18 (CK-18), fibroblast growth factor 21 (FGF-21), and combined biomarker panel (CBP) in the diagnosis of NAFLD, especially NASH.
A total of 25 studies met the inclusion criteria.
Pooled sensitivity and specificity values for chosen serum markers for diagnosing NASH are as follows: CK-18 (M30), 0.75 and 0.77; CK-18 (M65), 0.71 and 0.77; FGF-21, 0.62 and 0.78; and CBP, 0.92 and 0.85.
CBP demonstrated better accuracy with higher sensitivity and specificity than those tested individually.
Furthermore, the AUROC of CBP was 0.94 (95% CI, 0.92–0.96), compared to CK-18 or FGF-21 assay, which showed the most significant ability to distinguish NASH from simple steatosis.
The results suggest that increased circulating CK-18 and FGF-21 are associated with NASH and may be used for initial assessment, but not enough.
Importantly, CBP is potentially used as accurate diagnostic tools for NASH.
Further prospective designed studies are warranted to confirm our findings.
American Psychological Association (APA)
He, Lei& Deng, Linfeng& Zhang, Quan& Guo, Jianli& Zhou, Jinan& Song, Wenjian…[et al.]. 2017. Diagnostic Value of CK-18, FGF-21, and Related Biomarker Panel in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1139708
Modern Language Association (MLA)
He, Lei…[et al.]. Diagnostic Value of CK-18, FGF-21, and Related Biomarker Panel in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1139708
American Medical Association (AMA)
He, Lei& Deng, Linfeng& Zhang, Quan& Guo, Jianli& Zhou, Jinan& Song, Wenjian…[et al.]. Diagnostic Value of CK-18, FGF-21, and Related Biomarker Panel in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1139708
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139708