Naturally Occurring Resistance-Associated Variants to Hepatitis C Virus Direct-Acting Antiviral Agents in Treatment-Naive HCV Genotype 6a-Infected Patients
Joint Authors
Zhao, Zhixin
Li, Zhanyi
Lin, Guoli
Cai, Qing-xian
Liu, Ying
Zhang, Ying
Shao, Xiaoqiong
Luo, Qiumin
Guo, Xiaoyan
Chong, Yutian
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background and Objective.
The direct-acting antiviral agents (DAAs) antiviral therapy has drastically improved the prognosis of hepatitis C virus (HCV) patients.
However, the viral drug resistance-associated variants (RAVs) can limit the efficacy of DAAs.
For the HCV-6a is not the predominant prevalent genotype; the data on the prevalence of naturally occurring RAVs in it is scarce.
Our study aims to assess the prevalence of RAVs in treatment-naive HCV-6a patients.
Methods.
Nested PCR assays were performed on 95 HCV-6a patients to amplify HCV viral regions of NS3, NS5A, and NS5B.
Results.
In NS3/4A region, we detected Q80K in 95.5% isolates (84/88) and D168E in 2.3% isolates (2/88).
In NS5A region, we detected Q30R in 93.2% isolates (82/88), L31M in 4.6% isolates (4/88), and H58P in 6.8% isolates (6/88).
In NS5B region, we detected A15G in 2.3% isolates (2/88), S96T in 1.1% isolates (1/88), and S282T in 20.7% isolates (17/88) and we detected I482L in 100% isolates (4/4), V494A in 50% isolates (2/4), and V499A in 100% isolates (4/4).
Conclusions.
RAVs to DAAs preexist in treatment-naive HCV-6a patients.
Further studies should address the issue of the impact of RAVs in response to DAA therapies for HCV-6a patients.
American Psychological Association (APA)
Li, Zhanyi& Liu, Ying& Zhang, Ying& Shao, Xiaoqiong& Luo, Qiumin& Guo, Xiaoyan…[et al.]. 2017. Naturally Occurring Resistance-Associated Variants to Hepatitis C Virus Direct-Acting Antiviral Agents in Treatment-Naive HCV Genotype 6a-Infected Patients. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1139738
Modern Language Association (MLA)
Li, Zhanyi…[et al.]. Naturally Occurring Resistance-Associated Variants to Hepatitis C Virus Direct-Acting Antiviral Agents in Treatment-Naive HCV Genotype 6a-Infected Patients. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1139738
American Medical Association (AMA)
Li, Zhanyi& Liu, Ying& Zhang, Ying& Shao, Xiaoqiong& Luo, Qiumin& Guo, Xiaoyan…[et al.]. Naturally Occurring Resistance-Associated Variants to Hepatitis C Virus Direct-Acting Antiviral Agents in Treatment-Naive HCV Genotype 6a-Infected Patients. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1139738
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139738