Mice with Catalytically Inactive Cathepsin A Display Neurobehavioral Alterations
Joint Authors
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The lysosomal carboxypeptidase A, Cathepsin A (CathA), is a serine protease with two distinct functions.
CathA protects β-galactosidase and sialidase Neu1 against proteolytic degradation by forming a multienzyme complex and activates sialidase Neu1.
CathA deficiency causes the lysosomal storage disease, galactosialidosis.
These patients present with a broad range of clinical phenotypes, including growth retardation, and neurological deterioration along with the accumulation of the vasoactive peptide, endothelin-1, in the brain.
Previous in vitro studies have shown that CathA has specific activity against vasoactive peptides and neuropeptides, including endothelin-1 and oxytocin.
A mutant mouse with catalytically inactive CathA enzyme (CathAS190A) shows increased levels of endothelin-1.
In the present study, we elucidated the involvement of CathA in learning and long-term memory in 3-, 6-, and 12-month-old mice.
Hippocampal endothelin-1 and oxytocin accumulated in CathAS190A mice, which showed learning impairments as well as long-term and spatial memory deficits compared with wild-type littermates, suggesting that CathA plays a significant role in learning and in memory consolidation through its regulatory role in vasoactive peptide processing.
American Psychological Association (APA)
Calhan, O. Y.& Seyrantepe, V.. 2017. Mice with Catalytically Inactive Cathepsin A Display Neurobehavioral Alterations. Behavioural Neurology،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139771
Modern Language Association (MLA)
Calhan, O. Y.& Seyrantepe, V.. Mice with Catalytically Inactive Cathepsin A Display Neurobehavioral Alterations. Behavioural Neurology No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1139771
American Medical Association (AMA)
Calhan, O. Y.& Seyrantepe, V.. Mice with Catalytically Inactive Cathepsin A Display Neurobehavioral Alterations. Behavioural Neurology. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139771
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139771