Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats
Joint Authors
Slominsky, Petr A.
Kasian, Anastasiya
Kolomin, Timur
Andreeva, Lyudmila
Bondarenko, Elena
Myasoedov, Nikolay
Shadrina, Maria I.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
It was shown that the anxiolytic effect of Selank is comparable to that of classical benzodiazepine drugs and that the basis of their mechanism of action may be similar.
These data suggest that the presence of Selank may change the action of classical benzodiazepine drugs.
To test this hypothesis, we evaluated the anxiolytic activity of Selank and diazepam in rats both under conditions of unpredictable chronic mild stress and in its absence, after the individual and combined administration of these compounds using the elevated plus maze test.
We found that, even in the absence of chronic stress, the administration of a course of test substances changed anxiety indicators toward their deterioration, but the changes after the administration of a course of Selank were less pronounced.
In conditions of chronic stress, anxiety indicator values after the simultaneous use of diazepam and Selank did not differ from the respective values observed before chronic stress exposure.
The data obtained indicate that the individual administration of Selank was the most effective in reducing elevated levels of anxiety, induced by the administration of a course of test substances, whereas the combination of diazepam with Selank was the most effective in reducing anxiety in unpredictable chronic mild stress conditions.
American Psychological Association (APA)
Kasian, Anastasiya& Kolomin, Timur& Andreeva, Lyudmila& Bondarenko, Elena& Myasoedov, Nikolay& Slominsky, Petr A.…[et al.]. 2017. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behavioural Neurology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1139774
Modern Language Association (MLA)
Kasian, Anastasiya…[et al.]. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behavioural Neurology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1139774
American Medical Association (AMA)
Kasian, Anastasiya& Kolomin, Timur& Andreeva, Lyudmila& Bondarenko, Elena& Myasoedov, Nikolay& Slominsky, Petr A.…[et al.]. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behavioural Neurology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1139774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139774