Efficacy of a Computer-Assisted Cognitive Rehabilitation Intervention in Relapsing-Remitting Multiple Sclerosis Patients: A Multicenter Randomized Controlled Trial
Joint Authors
Grigoriadis, Nikolaos
Messinis, Lambros
Nasios, Grigorios
Kosmidis, Mary H.
Papathanasopoulos, Panagiotis
Malefaki, Sonia
Ntoskou, Katerina
Nousia, Anastasia
Bakirtzis, Christos
Gourzis, Philippos
Zampakis, Petros
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Cognitive impairment is frequently encountered in multiple sclerosis (MS) affecting between 40–65% of individuals, irrespective of disease duration and severity of physical disability.
In the present multicenter randomized controlled trial, fifty-eight clinically stable RRMS patients with mild to moderate cognitive impairment and relatively low disability status were randomized to receive either computer-assisted (RehaCom) functional cognitive training with an emphasis on episodic memory, information processing speed/attention, and executive functions for 10 weeks (IG; n=32) or standard clinical care (CG; n=26).
Outcome measures included a flexible comprehensive neuropsychological battery of tests sensitive to MS patient deficits and feedback regarding personal benefit gained from the intervention on four verbal questions.
Only the IG group showed significant improvements in verbal and visuospatial episodic memory, processing speed/attention, and executive functioning from pre - to postassessment.
Moreover, the improvement obtained on attention was retained over 6 months providing evidence on the long-term benefits of this intervention.
Group by time interactions revealed significant improvements in composite cognitive domain scores in the IG relative to the demographically and clinically matched CG for verbal episodic memory, processing speed, verbal fluency, and attention.
Treated patients rated the intervention positively and were more confident about their cognitive abilities following treatment.
American Psychological Association (APA)
Messinis, Lambros& Nasios, Grigorios& Kosmidis, Mary H.& Zampakis, Petros& Malefaki, Sonia& Ntoskou, Katerina…[et al.]. 2017. Efficacy of a Computer-Assisted Cognitive Rehabilitation Intervention in Relapsing-Remitting Multiple Sclerosis Patients: A Multicenter Randomized Controlled Trial. Behavioural Neurology،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1139779
Modern Language Association (MLA)
Messinis, Lambros…[et al.]. Efficacy of a Computer-Assisted Cognitive Rehabilitation Intervention in Relapsing-Remitting Multiple Sclerosis Patients: A Multicenter Randomized Controlled Trial. Behavioural Neurology No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1139779
American Medical Association (AMA)
Messinis, Lambros& Nasios, Grigorios& Kosmidis, Mary H.& Zampakis, Petros& Malefaki, Sonia& Ntoskou, Katerina…[et al.]. Efficacy of a Computer-Assisted Cognitive Rehabilitation Intervention in Relapsing-Remitting Multiple Sclerosis Patients: A Multicenter Randomized Controlled Trial. Behavioural Neurology. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1139779
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139779