Efficacy of a Computer-Assisted Cognitive Rehabilitation Intervention in Relapsing-Remitting Multiple Sclerosis Patients: A Multicenter Randomized Controlled Trial

Joint Authors

Grigoriadis, Nikolaos
Messinis, Lambros
Nasios, Grigorios
Kosmidis, Mary H.
Papathanasopoulos, Panagiotis
Malefaki, Sonia
Ntoskou, Katerina
Nousia, Anastasia
Bakirtzis, Christos
Gourzis, Philippos
Zampakis, Petros

Source

Behavioural Neurology

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-17, 17 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-12-31

Country of Publication

Egypt

No. of Pages

17

Main Subjects

Biology
Medicine

Abstract EN

Cognitive impairment is frequently encountered in multiple sclerosis (MS) affecting between 40–65% of individuals, irrespective of disease duration and severity of physical disability.

In the present multicenter randomized controlled trial, fifty-eight clinically stable RRMS patients with mild to moderate cognitive impairment and relatively low disability status were randomized to receive either computer-assisted (RehaCom) functional cognitive training with an emphasis on episodic memory, information processing speed/attention, and executive functions for 10 weeks (IG; n=32) or standard clinical care (CG; n=26).

Outcome measures included a flexible comprehensive neuropsychological battery of tests sensitive to MS patient deficits and feedback regarding personal benefit gained from the intervention on four verbal questions.

Only the IG group showed significant improvements in verbal and visuospatial episodic memory, processing speed/attention, and executive functioning from pre - to postassessment.

Moreover, the improvement obtained on attention was retained over 6 months providing evidence on the long-term benefits of this intervention.

Group by time interactions revealed significant improvements in composite cognitive domain scores in the IG relative to the demographically and clinically matched CG for verbal episodic memory, processing speed, verbal fluency, and attention.

Treated patients rated the intervention positively and were more confident about their cognitive abilities following treatment.

American Psychological Association (APA)

Messinis, Lambros& Nasios, Grigorios& Kosmidis, Mary H.& Zampakis, Petros& Malefaki, Sonia& Ntoskou, Katerina…[et al.]. 2017. Efficacy of a Computer-Assisted Cognitive Rehabilitation Intervention in Relapsing-Remitting Multiple Sclerosis Patients: A Multicenter Randomized Controlled Trial. Behavioural Neurology،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1139779

Modern Language Association (MLA)

Messinis, Lambros…[et al.]. Efficacy of a Computer-Assisted Cognitive Rehabilitation Intervention in Relapsing-Remitting Multiple Sclerosis Patients: A Multicenter Randomized Controlled Trial. Behavioural Neurology No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1139779

American Medical Association (AMA)

Messinis, Lambros& Nasios, Grigorios& Kosmidis, Mary H.& Zampakis, Petros& Malefaki, Sonia& Ntoskou, Katerina…[et al.]. Efficacy of a Computer-Assisted Cognitive Rehabilitation Intervention in Relapsing-Remitting Multiple Sclerosis Patients: A Multicenter Randomized Controlled Trial. Behavioural Neurology. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1139779

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1139779