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Neuroprotective and Antiamnesic Effects of Mitragyna inermis Willd (Rubiaceae) on Scopolamine-Induced Memory Impairment in Mice
Joint Authors
Taiwe, Germain Sotoing
Pahaye, David Bougolla
Bum, Elisabeth Ngo
Ngoupaye, Gwladys Temkou
Sidiki, Neteydji
Moto, Fleur Clarisse Okomolo
Kouemou, Nadège
Njapdounke, Stephanie Jacqueline Kameni
Nkantchoua, Gisele
Kandeda, Antoine
Omam, Jean Pierre Omam
Mairaira, Veronique
Ojong, Josiane Lucie
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Aim.
To assess memory improvement and neuroprotective and antioxidant effects of Mitragyna inermis (M.
inermis) leaf decoction on the central nervous system.
Methodology.
Leaf decoction of M.
inermis was tested on learning and memory in normal and scopolamine-induced cognitive impairment in mice using memory behavioral tests such as the Morris water maze, object recognition task, and elevated plus maze.
Oxidative stress enzymes—catalase, superoxide dismutase, and the thiobarbituric acid reactive substance, a product of lipid peroxidation—were quantified.
In each test, mice 18 to 25 g were divided into groups of 5.
Results.
The extract reversed the effects of scopolamine in mice.
The extract significantly increased discrimination index in the object recognition task test and inflexion ratio in the elevated plus maze test.
The times spent in target quadrant in MWM increased while the transfer latency decreased in mice treated by M.
inermis at the dose of 196.5 mg/kg.
The activity levels of superoxide dismutase and catalase were significantly increased, whereas the thiobarbituric acid reactive substance was significantly decreased after 8 consecutive days of treatment with M.
inermis at the dose of 393 mg/kg.
Conclusion.
These results suggest that M.
inermis leaf extract possess potential antiamnesic effects.
American Psychological Association (APA)
Pahaye, David Bougolla& Bum, Elisabeth Ngo& Taiwe, Germain Sotoing& Ngoupaye, Gwladys Temkou& Sidiki, Neteydji& Moto, Fleur Clarisse Okomolo…[et al.]. 2017. Neuroprotective and Antiamnesic Effects of Mitragyna inermis Willd (Rubiaceae) on Scopolamine-Induced Memory Impairment in Mice. Behavioural Neurology،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139780
Modern Language Association (MLA)
Pahaye, David Bougolla…[et al.]. Neuroprotective and Antiamnesic Effects of Mitragyna inermis Willd (Rubiaceae) on Scopolamine-Induced Memory Impairment in Mice. Behavioural Neurology No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1139780
American Medical Association (AMA)
Pahaye, David Bougolla& Bum, Elisabeth Ngo& Taiwe, Germain Sotoing& Ngoupaye, Gwladys Temkou& Sidiki, Neteydji& Moto, Fleur Clarisse Okomolo…[et al.]. Neuroprotective and Antiamnesic Effects of Mitragyna inermis Willd (Rubiaceae) on Scopolamine-Induced Memory Impairment in Mice. Behavioural Neurology. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139780
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139780