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The Protective Effect of Naringenin-Oxime on Cisplatin-Induced Toxicity in Rats
Joint Authors
Koyuncu, Ismail
Kocyigit, Abdurrahim
Gonel, Ataman
Arslan, Erkan
Durgun, Mustafa
Source
Biochemistry Research International
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of this study is to examine the protective effect of naringenin-oxime (NOX) on cisplatin-induced major organ toxicity and DNA damage in rats.
Thirty-five male Wistar albino rats were equally split into five groups as follows: control (i.p., 0.1 ml of saline), Cis administration (i.p., 7 mg/kg b.w.), NOX treatment (i.p., 20 mg/kg b.w., daily for ten days), Cis + NOX20, and Cis + NOX40 combination (i.p., 20 and 40 mg/kg b.w., daily for ten days).
Serum and peripheral blood mononuclear leukocytes (PBMC) were obtained from blood.
Malondialdehyde, glutathione, total antioxidant and oxidant status, and catalase were measured in serum, liver, and kidney, and oxidative stress index was calculated.
In parallel, paraoxonase and arylesterase activities were tested in liver and serum.
We used 8-OHdOG as a marker for DNA damage in serum via ELISA and in PMBC via comet assay.
Treatment with Cis elevated the levels of serum biochemical parameters, oxidative stress, and DNA damage.
Pretreatments of NOX restored biochemical and oxidative stress parameters in serum, renal, and liver tissues (p<0.01) and reduced 8-OHdG level, a finding further supported by comet assay in PBMC.
Observations of the present study support the fact that treatment with NOX prevents Cis-induced hepatotoxicity, nephrotoxicity, and genotoxicity by restoring antioxidant system.
American Psychological Association (APA)
Koyuncu, Ismail& Kocyigit, Abdurrahim& Gonel, Ataman& Arslan, Erkan& Durgun, Mustafa. 2017. The Protective Effect of Naringenin-Oxime on Cisplatin-Induced Toxicity in Rats. Biochemistry Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139804
Modern Language Association (MLA)
Koyuncu, Ismail…[et al.]. The Protective Effect of Naringenin-Oxime on Cisplatin-Induced Toxicity in Rats. Biochemistry Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1139804
American Medical Association (AMA)
Koyuncu, Ismail& Kocyigit, Abdurrahim& Gonel, Ataman& Arslan, Erkan& Durgun, Mustafa. The Protective Effect of Naringenin-Oxime on Cisplatin-Induced Toxicity in Rats. Biochemistry Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139804
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139804