Identification of Neuroprotective Factors Associated with Successful Ageing and Risk of Cognitive Impairment among Malaysia Older Adults
Joint Authors
Shahar, Suzana
Rajab, Nor Fadilah
Lau, Huijin
Mat Ludin, Arimi Fitri
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The increase of ageing population has raised public attention on the concept of successful ageing.
Studies have shown that vitamin D, telomere length, and brain-derived neurotrophic factor (BDNF) have been associated with cognitive function.
Therefore, this study aimed to identify neuroprotective factors for cognitive decline in different ageing groups.
A total of 300 older adults aged 60 years and above were recruited in this population based cross-sectional study.
Participants were categorized into three groups: mild cognitive impairment (MCI) (n=100), usual ageing (UA) (n=100), and successful ageing (SA) (n=100).
Dietary vitamin D intake was assessed through Diet History Questionnaire (DHQ).
Out of the 300 participants, only 150 were subjected to fasting blood sample collection.
These samples were used for serum vitamin D and plasma BDNF measurements.
Whole blood telomere length was measured using RT-PCR method.
The results show that the reduction of the risk of MCI was achieved by higher serum vitamin D level (OR: 0.96, 95% CI: 0.92–0.99, p<0.05), higher plasma BDNF level (OR: 0.51, 95% CI: 0.30–0.88, p<0.05), and longer telomere (OR: 0.97, 95% CI: 0.95–0.99, p<0.001).
In conclusion, participants with higher vitamin D level, higher BDNF level, and longer telomere length were more likely to age successfully.
American Psychological Association (APA)
Lau, Huijin& Mat Ludin, Arimi Fitri& Rajab, Nor Fadilah& Shahar, Suzana. 2017. Identification of Neuroprotective Factors Associated with Successful Ageing and Risk of Cognitive Impairment among Malaysia Older Adults. Current Gerontology and Geriatrics Research،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139824
Modern Language Association (MLA)
Lau, Huijin…[et al.]. Identification of Neuroprotective Factors Associated with Successful Ageing and Risk of Cognitive Impairment among Malaysia Older Adults. Current Gerontology and Geriatrics Research No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1139824
American Medical Association (AMA)
Lau, Huijin& Mat Ludin, Arimi Fitri& Rajab, Nor Fadilah& Shahar, Suzana. Identification of Neuroprotective Factors Associated with Successful Ageing and Risk of Cognitive Impairment among Malaysia Older Adults. Current Gerontology and Geriatrics Research. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139824
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139824