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Statin-Associated Necrotizing Autoimmune Myositis Complicated by an Uncommon Adverse Effect to Treatment
Joint Authors
Heinze, Emil R.
Fung, Brian M.
Wong, Andrew L.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Statin-associated necrotizing autoimmune myositis (NAM) is an autoimmune condition characterized by severe acute-onset proximal muscle weakness, a very high creatinine kinase (CK) level, and prominent myofiber necrosis and minimal lymphocytic infiltration on muscle biopsy.
Unlike self-limited statin myopathy, this condition usually requires aggressive immunomodulation therapy to assist recovery and prevent future disability.
In this case report, we present a patient who developed progressive muscle weakness after taking atorvastatin for one year.
At initial presentation, her CK level was 28,000 U/L.
She was diagnosed with statin-associated NAM and started on high-dose intravenous solumedrol, mycophenolate, and intravenous immunoglobulin (IVIG) therapy.
However, she subsequently developed acute bilateral vision loss and right side hemineglect; she was diagnosed with posterior reversible encephalopathy syndrome (PRES), thought to be a possible delayed adverse reaction to IVIG.
IVIG was discontinued, and the patient was treated with supportive therapy.
At six-month follow-up, she had significant improvement in muscle strength and vision.
American Psychological Association (APA)
Fung, Brian M.& Heinze, Emil R.& Wong, Andrew L.. 2019. Statin-Associated Necrotizing Autoimmune Myositis Complicated by an Uncommon Adverse Effect to Treatment. Case Reports in Medicine،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1140877
Modern Language Association (MLA)
Fung, Brian M.…[et al.]. Statin-Associated Necrotizing Autoimmune Myositis Complicated by an Uncommon Adverse Effect to Treatment. Case Reports in Medicine No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1140877
American Medical Association (AMA)
Fung, Brian M.& Heinze, Emil R.& Wong, Andrew L.. Statin-Associated Necrotizing Autoimmune Myositis Complicated by an Uncommon Adverse Effect to Treatment. Case Reports in Medicine. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1140877
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1140877