Dynamical Analysis of a Delayed HIV Virus Dynamic Model with Cell-to-Cell Transmission and Apoptosis of Bystander Cells

Abstract EN

In this paper, a delayed viral dynamical model that considers two different transmission methods of the virus and apoptosis of bystander cells is proposed and investigated.

The basic reproductive number R0 of the model is derived.

Based on the basic reproductive number, we prove that the disease-free equilibrium E0 is globally asymptotically stable for R0<1 by constructing suitable Lyapunov functional.

For R0>1, by regarding the time delay as bifurcation parameter, the existence of local Hopf bifurcation is investigated.

The results show that time delay can change the stability of endemic equilibrium and cause periodic oscillations.

Finally, we give some numerical simulations to illustrate the theoretical findings.