Successful Subsequent Pregnancy in a Woman Receiving Eculizumab for Pregnancy-Associated Atypical Haemolytic Uraemic Syndrome
Joint Authors
Bateman, Samantha
Ladhani, Maleeka
Jesudason, Shilpanjali
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-07
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Atypical haemolytic uraemic syndrome (aHUS) is a form of thrombotic microangiopathy precipitated by unopposed complement activation, the treatment of which has been revolutionised by the availability of the monoclonal anti-complement (C5) antibody, eculizumab.
Historically, women with aHUS would be unable to achieve a successful pregnancy due to the severity of their renal disease and for the few who could conceive, recurrence of aHUS was a significant risk.
In spite of this, parenthood remains a priority for many.
Experience with eculizumab use in the management of aHUS during pregnancy is growing and with it comes a significant change in the course of the disease.
We present the case of a 28-year-old woman diagnosed with severe aHUS in the first trimester of her first pregnancy.
She received rescue therapy with eculizumab and had a return to normal renal function.
While this pregnancy was lost, she strongly desired a family.
We managed her through a subsequent pregnancy while receiving eculizumab.
This pregnancy was uncomplicated and carried to term and she birthed a healthy 2500 g baby girl.
The complexities of managing a pregnancy in a woman with a history of aHUS are vast but not insurmountable, as demonstrated by this case.
American Psychological Association (APA)
Bateman, Samantha& Ladhani, Maleeka& Jesudason, Shilpanjali. 2019. Successful Subsequent Pregnancy in a Woman Receiving Eculizumab for Pregnancy-Associated Atypical Haemolytic Uraemic Syndrome. Case Reports in Nephrology،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1141060
Modern Language Association (MLA)
Bateman, Samantha…[et al.]. Successful Subsequent Pregnancy in a Woman Receiving Eculizumab for Pregnancy-Associated Atypical Haemolytic Uraemic Syndrome. Case Reports in Nephrology No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1141060
American Medical Association (AMA)
Bateman, Samantha& Ladhani, Maleeka& Jesudason, Shilpanjali. Successful Subsequent Pregnancy in a Woman Receiving Eculizumab for Pregnancy-Associated Atypical Haemolytic Uraemic Syndrome. Case Reports in Nephrology. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1141060
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141060