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Late Onset Graft Plasmacytoma-Like PTLD Presenting as Acute Hyperglycemia in a Kidney-Pancreas Transplant Recipient
Joint Authors
Aguiar, Pedro
Diekmann, Fritz
Cibeira, M. T.
Martinez, A.
Cuatrecasas, M.
Aymerich, M.
Ferrer, J.
Blade, J.
Ricart, M. J.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Allograft infiltration has been described in up to 20% of all patients with posttransplant lymphoproliferative disorder (PTLD), most representing EBV-positive B-cell lymphomas.
Plasma cells are often observed in humoral rejection biopsies, but graft infiltration by plasmacytoma-like PTLD is rare.
We report the case of a 54-year-old simultaneous pancreas-kidney transplant recipient (immunosuppression: OKT3, methylprednisolone, cyclosporine, and azathioprine), diagnosed with an IgG-kappa monoclonal gammopathy of undetermined significance eighteen years after transplant.
Nine months later, pancreas allograft biopsy performed due to new-onset hyperglycemia (HgA1C 8.6%, C-peptide 6.15ng/mL and anti-GAD 0.9UI/mL) revealed a monotypic plasma cell infiltrate, CD19, CD79a, CD138 positive, with IgG-kappa light chain restriction, and EBV negative.
PET-scan FDG uptake was limited to pancreas allograft.
Tumor origin could not be established (using DNA microsatellite analysis).
Despite treatment with bortezomib and dexamethasone, patient eventually died one month later.
This is the first report of a late onset extramedullary plasmacytoma involving a pancreas allograft.
American Psychological Association (APA)
Aguiar, Pedro& Cibeira, M. T.& Martinez, A.& Cuatrecasas, M.& Aymerich, M.& Ferrer, J.…[et al.]. 2019. Late Onset Graft Plasmacytoma-Like PTLD Presenting as Acute Hyperglycemia in a Kidney-Pancreas Transplant Recipient. Case Reports in Nephrology،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1141064
Modern Language Association (MLA)
Aguiar, Pedro…[et al.]. Late Onset Graft Plasmacytoma-Like PTLD Presenting as Acute Hyperglycemia in a Kidney-Pancreas Transplant Recipient. Case Reports in Nephrology No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1141064
American Medical Association (AMA)
Aguiar, Pedro& Cibeira, M. T.& Martinez, A.& Cuatrecasas, M.& Aymerich, M.& Ferrer, J.…[et al.]. Late Onset Graft Plasmacytoma-Like PTLD Presenting as Acute Hyperglycemia in a Kidney-Pancreas Transplant Recipient. Case Reports in Nephrology. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1141064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141064