Intravitreal Injection of Anti-VEGF Antibody Induces Glomerular Endothelial Cells Injury
Joint Authors
Geers, Caroline
Touzani, Fahd
Pozdzik, Agnieszka
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-22
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Introduction.
Antiangiogenic agents that inhibit vascular endothelial growth factor have emerged as important tools in cancer therapy and ocular diseases.
Their systemic use can induce renal limited microangiopathy.
Local use of anti-VEGF agent is supposed to be safe.
We report here a unique case of early endothelial cells injury induced by intravitreal injection of bevacizumab.
Case Presentation.
A 72-year-old man was addressed for acute kidney injury with proteinuria.
He was under treatment with intravitreal injections of bevacizumab for glaucoma.
Kidney biopsy was performed and electron microscopy showed signs of early stages of glomerular microangiopathy.
Bevacizumab was discontinued resulting in the improvement of renal function and albuminuria.
Discussion.
Bevacizumab, a humanized monoclonal antibody to VEGF is an approved therapy for metastatic cancer.
Systemic adverse events including thrombotic microangiopathy have been mainly reported after its systemic injection.
Podocytes produce VEGF that interacts with endothelial cells VEGF receptor-2 maintaining glomerular basement membrane integrity.
Bevacizumab induce the detachment of endothelial cells from glomerular basement membrane leading to the proteinuria and renal function decline.
Intravitreal bevacizumab is generally supposed to be safe.
However, glomerular injury with microangiopathy features, even after intravitreal injection is possible.
Conclusion.
We report the electron microscopy evidence that intravitreal injection of anti-VEGF induces glomerular endothelial cells injury.
Nephrologists and ophthalmologists should be aware of this complication.
American Psychological Association (APA)
Touzani, Fahd& Geers, Caroline& Pozdzik, Agnieszka. 2019. Intravitreal Injection of Anti-VEGF Antibody Induces Glomerular Endothelial Cells Injury. Case Reports in Nephrology،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1141070
Modern Language Association (MLA)
Touzani, Fahd…[et al.]. Intravitreal Injection of Anti-VEGF Antibody Induces Glomerular Endothelial Cells Injury. Case Reports in Nephrology No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1141070
American Medical Association (AMA)
Touzani, Fahd& Geers, Caroline& Pozdzik, Agnieszka. Intravitreal Injection of Anti-VEGF Antibody Induces Glomerular Endothelial Cells Injury. Case Reports in Nephrology. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1141070
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141070