Late-Onset Neutropenia after Rituximab Treatment for Adult-Onset Nephrotic Syndrome

Abstract EN

A 41-year-old woman developed nephrotic syndrome at the age of 32 and was diagnosed with minimal change nephrotic syndrome based on a renal biopsy.

Although remission was achieved with administration of prednisolone (PSL) and cyclosporine, the nephrotic syndrome recurred.

She was also started on rituximab (RTX).

She developed late-onset neutropenia after RTX treatment (R-LON) and improved 17 days later.

Although the majority of R-LON cases undergo spontaneous remission, cases of death have been reported.

This report is intended to warn about R-LON, since the use of RTX for adult-onset nephrotic syndrome is expected to increase in the future.